NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001346
CAS NUMBER: 100-42-5
BASE CHEMICAL NAME: STYRENE
PRIMARY NAME: STYRENE
CHEMICAL FORMULA: C8H8
STRUCTURAL FORMULA:
WLN: 1U1R
SYNONYMS:
ETHENYLBENZENE
PHENYLETHYLENE
VINYLBENZENE
STYROL
STYROLENE
CINNAMENE
CINNAMOL
CINNAMENOL
DIAREX HF 77
PHENETHYLENE
PHENYLETHENE
STYRON
STYROPOL
STYROPOR
VINYLBENZOL
STYRENE MONOMER
UN 2055
STYROLE
NCI-C02200
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Colorless to yellowish, oily liquid
REPOSITORY: Clear liquid
MOLECULAR WEIGHT: 104.16
SPECIFIC GRAVITY: 0.9060 @ 20/4 C
DENSITY: 0.909 g/cc @ 20 C (RAD)
MP (DEG C): -31 to -30.6 C
BP (DEG C): 145-146 C
SOLUBILITIES:
WATER : <1 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : >=100 mg/mL @ 19 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 19 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Methanol: Soluble
Carbon disulfide: Soluble
Petroleum ether: Soluble
ETHER : Soluble
BENZENE: Soluble
VOLATILITY:
Vapor pressure: 4.3 mm Hg @ 15 C; 9.5 mm Hg @ 30 C; 10 mm Hg @ 35 C
Vapor density : 1.1
FLAMMABILITY(FLASH POINT):
The flash point of this chemical is 31.1 C (88 F). It is flammable. Fires
involving this chemical should be controlled using a dry chemical, carbon
dioxide or Halon extinguisher. The autoignition temperature is 490 C (914 F).
UEL: 6.1% LEL: 1.1%
REACTIVITY:
Reacts violently with chlorosulfonic acid, oleum, H2SO4, and alkali metal
graphite. Reacts vigorously with oxidizing materials. Readily undergoes
polymerization when heated or exposed to light or a peroxide catalyst. The
polymerization releases heat and it may react violently. It is incompatible
with aluminum chloride. It can corrode copper and copper alloys.
STABILITY:
This chemical is sensitive to heat, light and may be sensitive to air. UV
spectrophotometric stability screening indicates that solutions of this com-
pound in ethanol are stable for 24 hours (RAD).
OTHER PHYSICAL DATA:
Freezing point: -33 C
Liquid surface tension: 32.14 dynes/cm
Liquid-water interfacial tension: 35.48 dynes/cm
Critical temperature: 373 C
Critical pressure: 39.46 atm
Odor Threshold: 0.148 ppm
Latent Heat of Vaporization: 156 Btu/lb
Heat of Polymerization: -277 Btu/lb
Penetrating odor
TOXICITY
NIOSH REGISTRY NUMBER: WL3675000
TOXICITY:
typ. dose mode specie amount unit other
LCLo ihl hmn 10000 ppm/30M
TCLo ihl hmn 600 ppm
TCLo ihl hmn 20 ug/m3
LD50 orl rat 5000 mg/kg
LD50 orl mus 316 mg/kg
LD50 ipr mus 660 mg/kg
LD50 ivn mus 90 mg/kg
LCLo ihl gpg 12 gm/m3/14H
LC50 ihl rat 24000 mg/m3/2H
LD50 ipr rat 1220 mg/kg
LC50 ihl mus 21600 mg/m3/2H
AQTX/TLM96: 100-10 ppm
SAX TOXICITY EVALUATION:
THR: MUTATION data. A skin and eye irritant. An experimental equivocal
tumorigenic agent and carcinogen. HIGH via oral and intravenous routes.
MODERATE via intraperitoneal and inhalation routes. A human irritant, has cen-
tral nervous system effects. It can cause irritation and violent itching
of the eyes.
CARCINOGENICITY:
Review: IARC Cancer Review: Human Inadequate Evidence
IARC Cancer Review: Animal Limited Evidence
IARC possible human carcinogen (Group 2B) [610]
Status: NCI Carcinogenesis Bioassay (Gavage); Negative: Male and Female Rat,
Female Mouse [620]
NCI Carcinogenesis Bioassay (Gavage); Equivocal: Male Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ------------------ | ---------- ------------------
mma-sat 1 umol/plate | mmo-smc 1 mmol/L
cyt-hmn:lym 300 ppm/72H | mrc-smc 1 mmol/L
sce-hmn:lym 500 umol/L | cyt-rat-ihl 300 ppm/8W-I
cyt-mus-orl 50 mg/kg | hma-mus/ssp 1 gm/kg
sce-mus-ihl 46400 ug/kg/4D-I | msc-ham:lng 240 umol/plate/4H
sce-mus-ihl 125 ppm/4D-I | dnd-rat:lvr 3 mmol/L
hma-mus/smc 1 gm/kg | otr-rat:emb 145 ug/plate
mnt-mus-ipr 250 mg/kg | dni-hmn:hla 28 mmol/L
dns-hmn:lym 100 umol/L | dnd-mus-ipr 10 mmol/kg
cyt-ham:lng 100 mg/L |
TERATOGENICITY:
Reproductive Effects Data:
TCLo: ihl-rat 300 ppm/7H (6-15D preg)
TCLo: ihl-mus 500 ppm/6H (6-16D preg)
TCLo: ihl-ham 1000 ppm/6H (6-18D preg)
TCLo: ihl-rat 5 mg/m3/24H (1-22D preg)
TCLo: ihl-rat 1500 ug/m3/24H (1-7D preg)
TCLo: ihl-rat 1500 ug/m3/24H (1-22D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 100 ppm; Ceiling Limit 200 ppm;
Peak 600 ppm/5M/3H [610]
Final Limit: PEL-TWA 50 ppm; STEL 100 ppm [610]
ACGIH: TLV-TWA 50 ppm (skin); STEL 100 ppm [610]
NIOSH Criteria Document: Recommended Exposure Limit to this compound-air:
TWA 50 ppm; Ceiling Limit 100 ppm [610]
NFPA Hazard Rating: Health (H): 2
Flammability (F): 3
Reactivity (R): 2
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R2: Materials which are normally unstable and readily undergo violent
chemical change but do not detonate (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-hmn 500 mg nse
skn-rbt 500 mg open MLD
skn-rbt 100% MOD
eye-rbt 18 mg
Review: Toxicology Review-5
Standards and Regulations: DOT-IMO: Flammable or Combustible liquid; Label:
Flammable liquid
DOT-Hazard: Flammable liquid; Label: Flammable
liquid
Status: "NIOSH Manual of Analytical Methods, 3rd. Ed."
Reported in EPA TSCA Inventory, 1983
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Section 8(e) Status Report 8EHQ-0179-0269 S
EPA Genetic Toxicology Program, January 1984
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Styrene monomer, inhibited
UN/ID NUMBER: UN2055
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
Manufacture of plastics, synthetic rubber, resins, insulator.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this compound emits acrid fumes. It is an eye
irritant. It may be narcotic in high concentrations.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep the
container tightly closed under an inert atmosphere, and store it in an
explosion-proof refrigerator. STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms following exposure to this compound may include weakness, irrita-
tion to the eyes and mucous membranes, conjunctivitis, central nervous system
depression, loss of coordination, drowsiness, lack of appetite, nausea and
vomiting and dermatitis. It is narcotic in high concentrations.
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