NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001012
CAS NUMBER: 102-06-7
BASE CHEMICAL NAME: DIPHENYLGUANIDINE,1,3-
PRIMARY NAME: 1,3-DIPHENYLGUANIDINE
CHEMICAL FORMULA: C13H13N3
STRUCTURAL FORMULA: HN=C(NHC6H5)2
WLN: MUYMR&MR
SYNONYMS:
DIPHENYLGUANIDINE
N,N'-DIPHENYLGUANIDINE
DPG
MELANILINE
SYM-DIPHENYLGUANIDINE
NCI-C60924
DPG ACCELERATOR
USAF EK-1270
USAF B-19
VULCACID D
VULKACIT D/C
VULKAZIT
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White to cream-colored powder
REPOSITORY: White chalky powder
MOLECULAR WEIGHT: 211.27
SPECIFIC GRAVITY: 1.13 @ 20/4 C [017,047]
DENSITY: 1.15 g/mL @ 25 C [042]
MP (DEG C): 150 C [017,025,031,205]
BP (DEG C): Decomposes >170 C [017,031,058,205]
SOLUBILITIES:
WATER : <1 mg/mL @ 21 C (RAD)
DMSO : 10-50 mg/mL @ 19 C (RAD)
95% ETHANOL : 10-50 mg/mL @ 19 C (RAD)
METHANOL : Not available
ACETONE : 1-10 mg/mL @ 19 C (RAD)
TOLUENE : Soluble in hot [031]
OTHER SOLVENTS:
Benzene: Soluble in hot [031,062,205]
Ether: >10% [047]
Carbon tetrachloride: Soluble [062]
Chloroform: Soluble [031,062,205]
Dilute mineral acids: Readily soluble [031]
Acids: Very soluble [205]
VOLATILITY:
Vapor pressure: Negligible [058]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 170 C (388 F) [058]. It is combustible.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. A water spray may also be used [058,269].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizers [269].
STABILITY:
This chemical is sensitive to moisture [058].
OTHER PHYSICAL DATA:
Monoclinic needles (in alcohol or toluene)
Crystals (in ether)
Bitter taste
Slight odor
1.0% Volatile by volume
Aqueous solutions are strongly alkaline
TOXICITY
NIOSH REGISTRY NUMBER: MF0875000
TOXICITY:
typ. dose mode specie amount units other
LD50 ipr mus 25 mg/kg
LD50 ipr rat 75 mg/kg
LDLo orl mam 250 mg/kg
LD50 orl mus 290 mg/kg
LD50 unr mus 258 mg/kg
LD50 unr rat 323 mg/kg
LD50 unr rbt 246 mg/kg
LD50 orl rat 507 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: HIGH via unknown, oral and intraperitoneal routes.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
bfa-mus/sat 36 ng/kg | mmo-sat 360 ng/plate
mma-sat 33 ug/plate |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-ham 224 mg/kg (56D male)
TDLo: orl-mus 76 mg/kg (1-19D preg)
TDLo: orl-mus 190 mg/kg (1-19D preg)
TDLo: orl-mus 56 mg/kg (7D male)
TDLo: orl-mus 196 mg/kg (49D male)
TDLo: orl-mus 140 mg/kg (35D male)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, June 1987
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
Primary standard for acids; accelerator for the vulcanization of rubber;
and complexing agent in the detection of metals and organic bases.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion [025,062,269]. It is harmful if inhaled
or absorbed through the skin. It is a severe eye irritant [269]. It is also
an irritant of the skin, eyes, mucous membranes and respiratory tract [058,
269]. When heated to decomposition it emits toxic fumes of carbon monoxide,
carbon dioxide, nitrogen oxides and organic amines [042,058,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-161 0.45 mm 240 min.
Neoprene Edmont 29-870 0.40 mm 240 min.
Nitrile Edmont 37-155 0.40 mm 240 min.
Viton North F-091 0.25 mm 480 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under ambient temperatures,
and protect it from moisture and oxidizers.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the skin,
eyes, mucous membranes and respiratory tract [058,269]. Other symptoms
include tearing, reddening and swelling of the skin and eyes; skin sensi-
tization (with possible blistering) and dermatitis. Inhalation may result
in runny nose, dry throat, sneezing, coughing and chest discomfort. Inges-
tion may result in nausea, vomiting and diarrhea. Conjunctivitis may occur
[058]. Eye contact may also cause punctuate corneal epithelial defects and
edema of the lids and conjunctiva [099].
SOURCES
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Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
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[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
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[052] Midwest Research Institute. MRI Report for 1,3-Diphenylguanidine.
Kansas City, MO. January 8, 1979.
[058] Information Handling Services. Material Safety Data Sheets
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[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
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[110] Oak Ridge National Laboratory. Environmental Mutagen Information
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[120] Oak Ridge National Laboratory. Environmental Teratogen Information
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[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
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[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
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[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
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[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
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[620] United States National Toxicology Program. Chemical Status Report.
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