NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
1-VINYL-3-CYCLOHEXENE DIOXIDE
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IDENTIFIERS
CATALOG ID NUMBER: 000470
CAS NUMBER: 106-87-6
BASE CHEMICAL NAME: VINYLCYCLOHEXENEDIOXIDE,1-,3-
PRIMARY NAME: 1-VINYL-3-CYCLOHEXENE DIOXIDE
CHEMICAL FORMULA: C8H12O2
STRUCTURAL FORMULA: Not printable
WLN: T36 BOTJ E- BT3OTJ
SYNONYMS:
3-(EPOXYETHYL)-7-OXABICYCLO(4.1.0)HEPTANE
1,2-EPOXY-4-(EPOXYETHYL)CYCLOHEXANE
1-EPOXYETHYL-3,4-EPOXYCYCLOHEXANE
3-OXIRANYL-7-OXABICYCLO(4.1.0)HEPTENE
VINYL CYLCOHEXENE DIEPOXIDE
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
CHISSONOX 206
EP-206
3-(EPOXYETHYL)-7-OXABICYCLO(4.1.0)HEPTANE
3-(1,2-EPOXYETHYL)-7-OXABICYCLO(4.1.0)HEPTANE
4-(1,2-EPOXYETHYL)-7-OXABICYCLO(4.1.0)HEPTANE
4-(EPOXYETHYL)-7-OXABICYCLO(4.1.0)HEPTANE
ERLA-2270
ERLA-2271
1-ETHYLENEOXY-3,4-EPOXYCYCLOHEXANE
NCI-C60139
UCET TEXTILE FINISH 11-74 (OBS.)
UNOX EPOXIDE 206
4-VINYLCYCLOHEXENE DIEPOXIDE
4-VINYL-1,2-CYCLOHEXENE DIEPOXIDE
4-VINYLCYCLOHEXENE DIOXIDE
4-VINYL-1-CYCLOHEXENE DIOXIDE
4-VINYL-1,2-CYCLOHEXENE DIEPOXIDE
4-VINYLCYCLOHEXENE DIOXIDE
4-VINYL-1-CYCLOHEXENE DIOXIDE
VINYL CYCLOHEXENE DIOXIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 140.20
SPECIFIC GRAVITY: 1.0986 @ 20/20 C [017,047,395,430]
DENSITY: Not available
MP (DEG C): <-55 C [017,047]
BP (DEG C): 227 C @ 760 mm Hg [395,430]
SOLUBILITIES:
WATER : 50-100 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
VOLATILITY:
Vapor pressure: 0.1 mm Hg @ 20 C [421,430]
Vapor density : 4.07 [430]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 110 C (230 F) [042,062,421]. It
is combustible. Fires involving this material can be controlled with a
dry chemical, carbon dioxide or Halon extinguisher. A water spray may
also be used [042].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical reacts with active hydrogen compounds (such as alcohols
and amines) [395].
STABILITY:
This chemical is slowly hydrolyzed in water [395]. Proton NMR stability
screening indicates that solutions of this material in neutral water are stable
for less than 4 hours (RAD).
OTHER PHYSICAL DATA:
Boiling point: 110-113 C @ 20 mm Hg [395]; 92 C @ 5 mm Hg [017,047]
Sets to glass @ -55 C [395,430]
Freezing point: -108.9 C [421]
Viscosity: 7.77 centipoise @ 20 C [062,421]
Refractive index: 1.4787 @ 20 C [017,042,395,430]
Faint olefinic odor [430]
TOXICITY
NIOSH REGISTRY NUMBER: RN8640000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 2130 mg/kg
LC50 ihl rat 800 ppm/4H
LD50 skn rbt 620 mg/kg
LD50 unr rbt 680 ug/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MODERATE via oral, inhalation and dermal routes. An experimental
carcinogen and equivocal tumorigenic agent. MUTATION data.
*CARCINOGENICITY:
Tumorigenic Data:
TDLo: ipr-rat 5000 mg/kg/10W-I
TDLo: skn-mus 56 gm/kg/47W-I
TDLo: unr-mus 2800 mg/kg
TD : skn-mus 90 gm/kg/74W-I
TD : skn-mus 12 gm/kg/9W-I
Review: IARC Cancer Review: Animal Limited Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [610]
Status: ACGIH suspected human carcinogen [610]
NTP Carcinogenesis Studies (Skin Paint); Clear Evidence: Male and
Female Rat, Male and Female Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-sat 50 ug/plate | mmo-smc 25 mmol/L
mma-sat 50 ug/plate | mrc-smc 25 mmol/L
mmo-klp 1 mmol/L | cyt-rat-ipr 125 mg/kg
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89)
Final Limit: PEL-TWA 10 ppm (skin) [610]
ACGIH: TLV-TWA 10 ppm (skin) [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 545 mg open MLD
skn-rbt 500 mg SEV
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Poisonous liquids, n.o.s.
(1-Vinyl-3-cyclohexene dioxide)
UN/ID NUMBER: UN2810
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 611, Y611 MAXIMUM QUANTITY: 60 L, 2 L
CARGO : PKG. INSTR.: 618 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
This chemical is used as a reactive diluent for other diepoxides and for
epoxy resins derived from bisphenol-A and epichlorohydrin. It has also been
proposed for use as a chemical intermediate (for condensation with dicarboxylic
acids) and as a monomer (for preparation of polyglycols containing unreacted
epoxy groups or for homo-polymerization to a three-dimensional resin). It is
used by the plastics industry in the formation of polymers and in other types
of organic synthesis.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a strong skin and tissue irritant [062].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PVA Edmont 25-545 0.61 mm 240 min.
PE/EVOH/PE Safety 4 4H 0.07 mm 240 min.
Viton North F-091 0.27 mm 240 min.
Butyl rubber North B-161 0.38 mm 480 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include strong skin and tissue
irritation [062,107]. It may also cause central nervous system depression
[107,430]. Other symptoms include testicular atrophy, conjunctivitis, eye and
skin inflammation, mucous membrane irritation, vesiculation, blistering,
dyspnea, difficulty in breathing, dermatitis, respiratory failure and coughing
[107].
Symptoms of exposure in animals include lung congestion, leukopenia and
necrosis of the thymus [346,421]. Other symptoms in animals include
vasodilation, unstable gait and liver congestion [430]. It has also caused
chronic pulmonary edema [015].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. RN8640000.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-225, #5529.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. p. 323.
[042] Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 2729.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 479, #C-01780.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 1223.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. October 4, 1988.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 199.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. pp. 921-922.
[395] International Agency for Research on Cancer, World Health
Organization. IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. Vol. 11, pp.
141-144.
[414] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1987-1988. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1987. pp. 36, 42.
[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 627.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIA, pp. 2194-2195.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 44.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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