NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
BIS(2-CHLORO-1-METHYLETHYL) ETHER
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IDENTIFIERS
CATALOG ID NUMBER: 000581
CAS NUMBER: 108-60-1
BASE CHEMICAL NAME: CHLOROMETHYLETHYLETHER,BIS,2-,1-
PRIMARY NAME: BIS(2-CHLORO-1-METHYLETHYL) ETHER
CHEMICAL FORMULA: C6H12Cl2O
STRUCTURAL FORMULA: [ClCH2C(CH3)H]2O
WLN: G1Y1&OY1&1G
SYNONYMS:
BETA,BETA'-DICHLORODIISOPROPYL ETHER
BIS(BETA-CHLOROISOPROPYL)ETHER
BIS(2-CHLOROISOPROPYL) ETHER
BIS(1-CHLORO-2-PROPYL) ETHER
DICHLOROISOPROPYL ETHER
DICHLORODIISOPROPYL ETHER
2,2'-DICHLOROISOPROPYL ETHER
DCIP
(2-CHLORO-1-METHYLETHYL) ETHER
2,2'-OXYBIS(1-CHLOROPROPANE)
NCI-C50044
UN 2490
RCRA WASTE NUMBER U027
ETHER, BIS(2-CHLORO-1-METHYLETHYL)
DCIP (NEMATOCIDE)
NEMAMORT
PROPANE, 2,2'-OXYBIS(1-CHLORO-
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless liquid
REPOSITORY: Light brown liquid
MOLECULAR WEIGHT: 171.07
SPECIFIC GRAVITY: 1.1122 @ 20/20 C [205,430]
DENSITY: Not available
MP (DEG C): -97 C [051,072]
BP (DEG C): 187.4 C @ 760 mm Hg [062]
SOLUBILITIES:
WATER : <0.1 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Organic solvents: Miscible [062,430]
Most oils: Miscible [062]
Ether: Soluble [017,047,395]
Benzene: Soluble [017,047,395]
Alcohol: Soluble [017]
VOLATILITY:
Vapor pressure: 0.10 mm Hg @ 20 C [043,062]; 1 mm Hg @ 29.6 C [395]
Vapor density : 6.0 [043,051,395,451]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 85 C (185 F) [051,062,169,451]. It
is combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [043,051].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with oxidizing materials [043,051,072].
STABILITY:
This chemical is sensitive to exposure to air and heat [051,072]. It
may also be sensitive to prolonged exposure to light. NMR stability screening
indicates that solutions of this chemical in DMSO are stable for at least
24 hours (RAD). It is stable for four days in isopropanol solution [052].
OTHER PHYSICAL DATA:
Refractive index: 1.4505 @ 20 C [047]
Viscosity: 0.0230 poise @ 20 C [430]
Specific gravity: 1.103 @ 20/4 C [017,047,395]
Log octanol/water partition coefficient: 2.58 [051,395]
Odor threshold: 200 ug/L [051,072,430]
TOXICITY
NIOSH REGISTRY NUMBER: KN1750000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 240 mg/kg
LCLo ihl rat 700 ppm/5H
LD50 skn rbt 3000 mg/kg
LD50 orl mus 296 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion. Moderately toxic by skin contact and inhalation.
An eye irritant. Mutagenic data.
CARCINOGENICITY:
Review: IARC Cancer Review: Animal Limited Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [015,610]
Status: NCI Carcinogenesis Bioassay (Gavage); Negative: Male and Female Rat
[620]
NCI Carcinogenesis Bioassay (Gavage); Positive: Male and Female
Mouse [620]
MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mma-sat 333 ug/plate | mmo-sat 1 gm/plate
msc-mus:lym 250 mg/L | cyt-ham:ovr 124 mg/L
sce-ham:ovr 11300 ug/L |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
AIHA: Workplace Environmental Exposure Level (WEEL): TWA 3 ppm [651]
NFPA Hazard Rating: Health (H): 2
Flammability (F): 2
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 500 mg open
eye-rbt 500 mg/24H MLD
skn-rbt 500 mg/24H MLD
Standards and Regulations: DOT-Hazard: Corrosive Material; Label: Corrosive
DOT-IMO: Poison B; Label: Poison
Status: EPA TSCA Chemical Inventory, 1989
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Dichloroisopropyl ether
UN/ID NUMBER: UN2490
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 609, Y609 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 611 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used in laboratories and in industrial organic synthesis.
It is also used in textile treatments, preparation of ion exchange resins,
pesticide manufacturing, solvents for polymerization reactions, processing
fats, waxes and greases, textile manufacturing, cleaning solution manufac-
turing, paints and varnishes, spotting agents and control of nematodes.
COMMENTS:
This compound is probably a mixture of diastereoisomers [026].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is an irritant of the eyes and respiratory tract [051,072].
It may be absorbed through the skin [430]. It is a corrosive material [043].
When heated to decomposition it emits highly toxic fumes of chlorine [043,051,
072].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PVA Edmont PVA 0.33 mm 240 min
Neoprene Edmont 29-870 0.62 mm 240 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
positive pressure supplied-air respirator or a self-contained breathing
apparatus (SCBA).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures. Keep it away from oxidizing materials.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include toxic effects to the liver
and kidneys [430]. It may cause skin and respiratory tract irritation
[051,072].
SOURCES
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