NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000851
CAS NUMBER: 108-91-8
BASE CHEMICAL NAME: CYCLOHEXYLAMINE
PRIMARY NAME: CYCLOHEXYLAMINE
CHEMICAL FORMULA: C6H13N
STRUCTURAL FORMULA:
WLN: L6TJ AZ
SYNONYMS:
AMINOCYCLOHEXANE
AMINOHEXAHYDROBENZENE
HEXAHYDROANILINE
CHA
CYCLOHEXANAMINE
HEXAHYDROBENZENAMINE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: CLEAR COLORLESS LIQUID
MOLECULAR WEIGHT: 99.17
SPECIFIC GRAVITY: 0.8467 @ 25/25 DENSTIY: 0.85 g/mL @25
DENSITY: 3.42 ELL: 1.5% ELU
MP (DEG C): -17.7
BP (DEG C): 134.5
SOLUBILITIES:
WATER : VERY SOLUBLE
DMSO : VERY SOLUBLE
95% ETHANOL : VERY SOLUBLE
METHANOL : Not available
ACETONE : VERY SOLUBLE
TOLUENE : Not available
OTHER SOLVENTS: Not available
ETHER : VERY SOLUBLE
BENZENE: VERY SOLUBLE
VOLATILITY : MODERATE.
Vapor density : 3.42
FLAMMABILITY(FLASH POINT): HIGH. ?FLASH POINT: 110 DEGREES F. NO DANGEROUS R
The autoignition temperature is 293 C (559 F).
UEL: 9.4% LEL: Not available
REACTIVITY: MAY REACT VIOLENTLY WITH OXIDIZING MATERIALS.
STABILITY: Sensitive to air and light
OTHER PHYSICAL DATA: Strong, fishy amine odor.
TOXICITY
NIOSH REGISTRY NUMBER: GX0700000
TOXICITY:
typ. dose mode specie amount unit other
LD50 ORL RAT 710 MG/KG
LD50 IPR RAT 200 MG/KG
LD50 IPR MUS 300 MG/KG
LD50 SCU MUS 1150 MG/KG
LD50 SKN RBT 320 MG/KG
LDLO PAR RBT 500 MG/KG
AQTX/TLM96: 1000-100 PPM
SAX TOXICITY EVALUATION: THR=MODERATE VIA ORAL AND INHALATION ROUTES; HIGH VIA
CARCINOGENICITY: Not available
MUTAGENICITY:
CYT-HMN:LEU 10 UMOL/L/5H
CYT-RAT-UNK 50 MG/KG
SPM-RAT-IPR 5 MG/KG/5D
DLT-MUS-IPR 500 MG/KG/5D-I
CYT-HAM:FBR 10 MG/L
CYT-DOM-UNK 50 MG/KG
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89)
Final Limit: PEL-TWA 10 ppm [610]
ACGIH: TLV-TWA 10 ppm [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 3
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-hmn 125 mg/48H SEV
Review: Toxicology Review-2
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Cyclohexylamine
UN/ID NUMBER: UN2357
HAZARD CLASS: 8 SUBSIDIARY RISK: 3 PACKING GROUP: II
LABELS REQUIRED: Corrosive and Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 808, Y808 MAXIMUM QUANTITY: 1 L, 0.5 L
CARGO : PKG. INSTR.: 812 MAXIMUM QUANTITY: 30 L
SPECIAL PROVISIONS: None
USES:
IN ORGANIC SYNTHESIS, MANUFACTURE OF INSECTICIDES, PLASTICIZERS, CORROSION
INHIBITORS, RUBBER CHEMICALS, DYESTUFFS, EMULSIFYING AGENT, DRY CLEANING
SOAPS, ACID GAS ABSORBENTS. PAINT, PIGMENT, SURFACTANT, INSECTICIDE, OXYGEN
ABSORBER. BOILER WATER TREATMENT, RUBBER ACCELERATOR.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
TOXIC. CAUSES IRRITATION ON CONTACT. HIGHLY TOXIC DECOMPOSITION
PRODUCTS. ?MUTAGEN.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS: P
The following gloves show the best resistance based on permeation
testing. It is recommended that two different glove types be used for
best protection. However, if this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, remove them at once.
SUGGESTED GLOVES: Butyl rubber (to 160 min.)
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical in a freezer and away from all
mineral acids and bases.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a strong soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center.
Generally, the induction of vomiting is NOT recommended outside of a
physician's care due to the risk of aspirating the chemical into the victim's
lungs. However, if the victim is conscious and not convulsing and if medical
help is not readily available, consider the risk of inducing vomiting because
of the high toxicity of the chemical ingested. Ipecac syrup or salt water may
be used in such an emergency. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS: MAY CAUSE IRRITATION ON CONTACT. CAUSES NAUSEA AND NARCOTIC EFFECTS
FIREFIGHTING:
This compound is not very flammable but any fire involving this compound
may produce dangerous vapors. You should evacuate the area. All firefighters
should wear full-body protective clothing and use self-contained breathing
apparatuses.
You should extinguish any fires involving this chemical with a dry
chemical, carbon dioxide, foam, or halon extinguisher.
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic
Effects of Chemical Substances. DHEW (NIOSH) Publication
No. 79-100. National Institute for Occupational Safety
and Health. Cincinnati, OH. 1979. GX0700000.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. LISTED.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. PP.357, NO.2734.
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. PP.145-146, NO.183.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 60th Ed. CRC Press, Inc. Boca Raton, FL.
1982. PP.C-260, NO.C640.
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. NOT LISTED.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. PP.298.
Sax, N.I. Dangerous Properties of Industrial Materials. 4th Ed.
Van Nostrand Reinhold. New York. 1975. PP.530.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. LISTED.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. PP.750-751, NO.308.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. LISTED.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemicals. Aldrich Chemical Co., Inc. Milwaukee, WI.
1980. PP.271, NO.C10,465-5.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. NOT LISTED.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxviii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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