NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002300
CAS NUMBER: 111-02-4
BASE CHEMICAL NAME: SQUALENE,TRANS-
PRIMARY NAME: TRANS-SQUALENE
CHEMICAL FORMULA: C30H50
STRUCTURAL FORMULA: Not printable
WLN: Not available
SYNONYMS:
2,6,10,14,18,22-TETRACOSAHEXAENE, 2,6,10,15,19,23-HEXAMETHYL-, (ALL-E)-
2,6,10,15,19,23-HEXAMETHYL-2,6,10,14,18,22-TETRACOSAHEXAENE
SPINACENE
ALL-TRANS-SQUALENE
TRANS-SPINACENE
SQUALENE
SPINACEN
SQUALEN
(E,E,E,E)-SQUALENE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Oil
REPOSITORY: Clear, slightly yellow liquid
MOLECULAR WEIGHT: 410.73
SPECIFIC GRAVITY: 0.8584 @ 20/4 C [016,033,205,430]
DENSITY: 0.858 g/mL [269,275]
MP (DEG C): -75 C [033,055,205,275]
BP (DEG C): 285 C @ 25 mm Hg [055,205,269,275]
SOLUBILITIES:
WATER : <1 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : <1 mg/mL @ 19 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 19 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: Soluble [033,047,205,430]
Alcohol: Slightly soluble [033,205,430]
Petroleum ether: Soluble [033,205]
Carbon tetrachloride: Soluble [033]
Other fat solvents: Soluble [033]
Glacial acetic acid: Sparingly soluble [033]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of >112 C (>235 F) [269]. It is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizing agents [269].
STABILITY:
This chemical may discolor on exposure to air [269]. Solutions of this
chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours
under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Absorbs oxygen and becomes viscous like linseed oil [033]
Faint odor [055]
Refractive index: 1.4990 @ 20 C [016,047,430]
Boiling point: 280 C @ 17 mm Hg; 240-242 C @ 4 mm Hg [047]
Viscosity: 12 centipoise @ 25 C [033]
Melting point: <-20 C [016,047,430]
TOXICITY
NIOSH REGISTRY NUMBER: XB6010000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl mus 5 gm/kg
LD50 ivn mus 1800 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Not available
CARCINOGENICITY: Not available
MUTATION DATA: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA TSCA Chemical Inventory, 1989
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This chemical is used in biochemical and pharmaceutical research. It is
an intermediate in the biosynthesis of cholesterol; a bactericide; an inter-
mediate in the manufacture of pharmaceuticals, organic coloring materials,
rubber chemicals, aromatics and surface active agents.
COMMENTS:
This compound is found in large quantities in shark oil [033].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this compound emits toxic fumes of carbon
monoxide and carbon dioxide [269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-161 0.49 mm 480 min
Nitrile Edmont 37-155 0.35 mm 360 min
Neoprene Pioneer N-44 0.56 mm 240 min
PE/EVAL/PE Safety 4 4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
SPILLS AND LEAKAGE:
If you should spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION,
then use absorbent paper to pick up all liquid spill material. Your contamina-
ted clothing and absorbent paper should be sealed in a vapor-tight plastic bag
for eventual disposal. Solvent wash all contaminated surfaces with acetone
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Information concerning symptoms of exposure to this chemical is not
available.
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. XB6010000.
August 10, 1990.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-494, #13373
[029] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. and
Supplements. Chapman and Hall. New York. 1988. Vol. 5, p. 5044,
#S-00709.
[033] Budavari, Susan, Ed. The Merck Index. 11th Ed. Merck and Co., Inc.
Rahway, NJ. 1989. p. 1383, #8726.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. II, p. 294, #S00420.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
p. 1052.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
Fragrance Assn. Inc. Washington. 1982. p. 298.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-618, #S-15.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1617, #D.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 1358, #22,316-6.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIC, pp. 3196-3197.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Not listed.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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