NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000276
CAS NUMBER: 133-06-2
BASE CHEMICAL NAME: CAPTAN
PRIMARY NAME: CAPTAN
CHEMICAL FORMULA: C9H8Cl3NO2S
STRUCTURAL FORMULA: Not printable
WLN: T56 BVNV GUTJ CSXGGG
SYNONYMS:
N-TRICHLOROMETHYLMERCAPTO-4-CYCLOHEXENE-1,2-DICARBOXIMIDE
N-(TRICHLOROMETHYLMERCAPTO)-DELTA(SUP 4)TETRAHYDROPHTHALIMIDE
N-((TRICHLOROMETHYL)THIO)TETRAHYDROPHTHALIMIDE
N-TRICHLOROMETHYLTHIO-3A,4,7,7A-TETRAHYDROPHTHALIMIDE
3A,4,7,7A-TETRAHYDRO-2-((TRICHLOROMETHYL)THIO)-1H-ISOINDOLE-1,3(2H)-DIONE
4-CYCLOHEXENE-1,2-DICARBOXIMIDE, N-(TRICHLOROMETHYL)THIO-
N-(TRICHLOROMETHYL)THIO-4-CYCLOHEXENE-1,2-DICARBOXIMIDE
1H-ISOINDOLE-1,3(2H)-DIONE, 3A,4,7,7A-TETRAHYDRO-2-((TRICHLOROMETHYL)THIO)-
CAPTAF
CAPTAF 85W
CAPTANCAPTENEET 26,538
CAPTANE
CAPTEX
ENT 26,538
ESSOFUNGICIDE 406
FLIT 406
FUNGUS BAN TYPE II
GLYODEX 3722
MERPAN
ORTHOCIDE
ORTHOCIDE 7.5
ORTHOCIDE 50
ORTHOCIDE 406
SR406
STAUFFER CAPTAN
VANCIDE 89
VANGARD K
VONDCAPTAN
NCI-C00077
N-TRICHLOROMETHYLTHIOCYCLOHEX-4-ENE-1,2-DICARBOXIMIDE
N-(TRICHLOROMETHYLTHIO)CYCLOHEX-4-ENE-1,2-DICARBOXIMIDE
N-TRICHLOROMETHYLTHIO-CIS-DELTA(SUP 4)-CYCLOHEXENE-1,2-DICARBOXIMIDE
N-((TRICHLOROMETHYL)THIO)-4-CYCLOHEXENE-1,2-DICARBOXIMIDE
TRICHLOROMETHYLTHIO-1,2,5,6-TETRAHYDROPHTHALAMIDE
AACAPTAN
AGROSOL S
AGROX 2-WAY AND 3-WAY
AMERCIDE
BANGTON
BEAN SEED PROTECTANT
CAPTAB
CAPTAN-STREPTOMYCIN 7.5-0.1 POTATO SEED PIECE PROTECTANT
CAPTAN 50W
GRANOX PFM
GUSTAFSON CAPTAN 30-DD
HEXACAP
KAPTAN
MALIPUR
MICRO-CHECK 12
NERACID
OSOCIDE
3A,4,7,7A-TETRAHYDRO-N-(TRICHLOROMETHANESULPHENYL)PHTHALIMIDE
1,2,3,6-TETRAHYDRO-N-(TRICHLOROMETHYLTHIO)PHTHALIMIDE
VANCIDE 89RE
VANCIDE P-75
VANGUARD K
VANICIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White crystals
REPOSITORY: Cream-colored powder
MOLECULAR WEIGHT: 300.59
SPECIFIC GRAVITY: 1.74 [031,169,395,421]
DENSITY: 1.74 g/mL [025,047]
MP (DEG C): 178 C [031,169,172,395]
BP (DEG C): Decomposes
SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : 50-100 mg/mL @ 20 C (RAD)
95% ETHANOL : <1 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : 1-5 mg/mL @ 20 C (RAD)
TOLUENE : 0.69 g/100 mL @ 26 C [031]
OTHER SOLVENTS:
Chloroform: 7.78 g/100 mL @ 26 C [031,169]
Tetrachloroethane: 8.15 g/100 mL @ 26 C [031]
Heptane: 0.04 g/100 mL @ 26 C [031]
Ethylene dichloride: Slightly soluble [062]
Ether: 0.25 g/100 mL @ 26 C [31]
Benzene: 21 g/kg @ 26 C [169]
Cyclohexanone: 23 g/kg @ 25 C [172,395]
Dioxane: 47 g/kg @ 26 C [169]
Isopropanol: 1.7 g/kg @ 26 C [169,395]
Methylene chloride: Soluble [025]
Petroleum oils: Insoluble [169,172,173,395]
Xylene: 20 g/kg @ 25 C [169,172,395]
VOLATILITY:
Vapor pressure: <0.00001 mm Hg @ 25 C [173,395]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong alkaline and oxidizing
materials, sulfur and (sulfur + moisture) [058].
STABILITY:
This chemical is slowly hydrolyzed in aqueous neutral and acidic media.
It is rapidly hydrolyzed in alkaline media. It decomposes at or near the
melting point [169]. UV spectrophotometric stability screening indicates
that solutions of this chemical in ethanol are stable for at least 24 hours
(RAD).
OTHER PHYSICAL DATA:
Melting point also reported as 158-164 C [062]
log P octanol: 2.35 [055]
Odorless [031,043]
TOXICITY
NIOSH REGISTRY NUMBER: GW5075000
TOXICITY:
typ. dose mode specie amount units other
LDLo orl hmn 1071 mg/kg
LD50 orl rat 9 gm/kg
LD50 unr rat 2650 mg/kg
LC50 ihl mus 5000 mg/m3/2H
LD50 ipr mus 30 mg/kg
LD50 unr mus 138 mg/kg
LD50 unr rbt 740 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately toxic to humans by ingestion. Moderately toxic experimentally
by ingestion, inhalation and intraperitoneal routes. An experimental
tumorigen, neoplastigen and teratogen. A suspected carcinogen. Experi-
mental reproductive effects. Human mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 1075 gm/kg/80W-C
TD : orl-mus 540 gm/kg/80W-C
Review: IARC Cancer Review: Animal Limited Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [015,395,610]
Status: NCI Carcinogenesis Bioassay (Feed); Negative: Male and Female Rat
[620]
NCI Carcinogenesis Bioassay (Feed); Positive: Male and Female Mouse
[620]
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: See RTECS printout for data
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Final Limit: PEL-TWA 5 mg/m3 [545,610]
ACGIH: TLV-TWA 5 mg/m3 [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review-2
Status: EPA Genetox Program 1988, Positive: Aspergillus-recombination; Rodent
dominant lethal
EPA Genetox Program 1988, Positive: Host-mediated assay; B subtilis
rec assay
EPA Genetox Program 1988, Positive: E coli polA without S9; Histidine
reversion-Ames test
EPA Genetox Program 1988, Positive: D melanogaster Sex-linked lethal
EPA Genetox Program 1988, Positive: V79 cell culture-gene mutation;
TRP reversion
EPA Genetox Program 1988, Positive: S cerevisiae gene conversion;
S cerevisiae-homozygosis
EPA Genetox Program 1988, Weakly Positive: TRP reversion
EPA Genetox Program 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA Genetox Program 1988, Negative: Aspergillus-aneuploidy; Body fluid
assay
EPA Genetox Program 1988, Negative: Rodent heritable translocation
EPA Genetox Program 1988, Negative: In vitro UDS-human fibroblast
EPA Genetox Program 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA Genetox Program 1988, Positive: CHO gene mutation
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, September 1989
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a fungicide in paints, plastics, leather and
fabrics, in fruit preservation and as a bacteriostat. It is used to control
diseases of many fruit, ornamentals and vegetable crops. It is also used as
a spray, root dip or seed treatment to protect young plants against rot and
damping off. It controls a wide range of fungal diseases such as pome fruit
rot, shot-hole of stone fruit, peach leaf curl, brown rot of cherries, apri-
cots, peaches, plums and citrus fruit, downy mildew and black rot of vines,
early and late blights of potatoes and tomatoes, blight and leaf spot in
carrots, anthracnose and downy mildew of cucurbits, leaf spot diseases in
ornamentals, anthracnose and leaf spot disease of tomatoes and brown patch
on turf. It is used in the topical treatment of fungal infections of the
skin. It is also used in pastes for wallpaper, in paint for greenhouses, in
medical facilities, in food packaging, in vinyl coated fabrics and vinyl car
roofs, in lacquers, in paper, in rubber stabilizers and in polyethylene for
garbage bags and pond liners.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may cause irritation [062]. When heated to decomposition
it emits toxic fumes of chlorine, sulfur oxides and nitrogen oxides [043].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical under ambient temperatures, and keep
it away from oxidizing materials.
SPILLS AND LEAKAGE:
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION,
then you should dampen the solid spill material with acetone and transfer the
dampened material to a suitable container. Use absorbent paper dampened with
acetone to pick up any remaining material. Seal your contaminated clothing
and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with acetone followed by washing with
a soap and water solution. Do not reenter the contaminated area until the
Safety Officer (or other responsible person) has verified that the area has
been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include vomiting and diarrhea
[031].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. GW5075000.
January 10, 1990.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, p. 981, #C-00183.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 244, #1745.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, p. 694, #CBG000.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 394, #C00275.
[051] Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials
Report. Bi-monthly Updates. Van Nostrand Reinhold Company, Inc.
New York. September/October 1983. Vol. 3, No. 5, p. 80.
[052] Midwest Research Institute. MRI Report for Captan. Kansas City, MO.
April 12, 1978.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
p. 334.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. December 1989/
January 1990. #9910-175, B-07.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 215.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-316, #1179.
[165] Wiswesser, W.J., Ed. Pesticide Index. Entomological Society
of America. College Park, MD. 1976. p. 37.
[169] Hartley, Douglas B.Sc., Ph.D., M.I.Inf.Sc. and Hamish Kidd B.Sc., Eds.
The Agrochemicals Handbook. 2nd Ed. The Royal Society of Chemistry.
Nottingham, England. 1987. Listed.
[172] Worthing, C.R., Ed. The Pesticide Manual, A World Compendium.
8th Ed. British Crop Protection Council. London, England.
1987. p. 123, #1940.
[173] Hayes, W.J., Jr. Pesticides Studied in Man. Williams and
Wilkins. Baltimore. 1982. p. 579.
[186] Sittig, Marshall, Ed. Pesticide Manufacturing and Toxic Materials
Control Encyclopedia. Noyes Data Corporation. Park Ridge, NJ.
1980. p. 134.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
Fragrance Assn. Inc. Washington. 1982. p. 40.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. pp. 720, 831.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. p. 181.
[395] International Agency for Research on Cancer, World Health
Organization. IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. Vol. 30, p. 295;
Supplement 7, p. 59.
[415] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 14.
[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 98.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIA, p. 2706.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
11th Edition. The Pharmaceutical Press. London. 1979. p. 667.
[545] Office of the Federal Register National Archives and Records
Administration. Federal Register, Dept. of Labor, Part III.
U.S. Government Printing Office. Washington. January 19, 1989.
p. 2926.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 56.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
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