NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
ETHYL ACRYLATE (INHIBITED)
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IDENTIFIERS
CATALOG ID NUMBER: 000599
CAS NUMBER: 140-88-5
BASE CHEMICAL NAME: ETHYLACRYLATEINHIBITED
PRIMARY NAME: ETHYL ACRYLATE (INHIBITED)
CHEMICAL FORMULA: C5H8O2
STRUCTURAL FORMULA: H2C=CHCOOCH2CH3
WLN: 2OV1U1
SYNONYMS:
ETHYL ACRYLATE
ACRYLIC ACID, ETHYL ESTER (INHIBITED)
PROPENOIC ACID, ETHYL ESTER (INHIBITED)
ETHYL PROPENOATE
ETHOXYCARBONYLETHYLENE
ETHYL 2-PROPENOATE
2-PROPENOIC ACID, ETHYL ESTER
NCI-C50384
RCRA WASTE NUMBER U113
UN 1917
ETHYL ACRYLATE, INHIBITED
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 100.12
SPECIFIC GRAVITY: 0.9234 @ 20/4 C [017,047,395]
DENSITY: Not available
MP (DEG C): -71.2 C [047,205,395,421]
BP (DEG C): 99.8 C [017,043,051,395]
SOLUBILITIES:
WATER : 10-50 mg/mL @ 21 C (RAD)
DMSO : >=100 mg/mL @ 21 C (RAD)
95% ETHANOL : >=100 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Soluble [017,047,395]
Ether: Soluble [017,031,047,062]
Alcohol: Soluble [017,031,062,205]
VOLATILITY:
Vapor pressure: 29.3 mm Hg @ 20 C [043,051,421,430]; 40 mm Hg @ 26 C [038]
Vapor density : 3.45 [031,043,421,430]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 9 C (48 F) [102]. It is flammable.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. The autoignition temperature of this chemical
is 383 C (721 F) [102,421].
UEL: 12.1% [058] LEL: 1.8% [043,051,058,430]
REACTIVITY:
This compound is incompatible with oxidizers, peroxides, strong alkalies
and polymerization initiators [058,346,395]. It is also incompatible with
acids [269]. It will react violently with chlorosulfonic acid [043,051]. It
readily polymerizes without the presence of an inhibitor (polymerization is
speeded up by exposure to light) [031,395].
STABILITY:
This compound is sensitive to exposure to moisture, light and heat [058].
It may polymerize when exposed to light [031,269]. High temperatures can
negate the effects of inhibitors. It is subject to slow hydrolysis [051].
Inhibitors do not function in the absence of air [102]. Proton NMR stability
screening indicates that solutions of this material in DMSO are stable for
at least 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
This compound is inhibited.
Odor threshold: 0.47 ppb [430]
Evaporation rate (butyl acetate=1): 3.3 [058,102]
Powerful, unpleasant, acrid, ester-like odor [058]
Refractive index: 1.4068 @ 20 C [017,047,205,430]
Ultraviolet maximum (epsilon = 692): 208 nm [395]
Specific gravity: 0.9230 @ 20/20 C [062,371]
Boiling point: 20 C @ 39.2 mm Hg [031]; 95 C @ 746.3 mm Hg [052]
Specific heat: 0.442 cal/g/C @ -60 C [031]
Bulk density: 7.6 lb/gal @ 20 C [062]
Heat of vaporization: 8.27 kcal/mol [031]
Heat of combustion: 655.49 kcal/mol [031]
Forms an azeotrope with water containing 45% water (boiling point of
81 C) [031]
Forms an azeotrope with ethanol containing 56.8% ethanol (boiling point of
76 C) [031]
Liquid surface tension: 25 dynes/cm [371]
Liquid water interfacial tension: 40 dynes/cm [371]
Specific heat of vapor (gas): 1.080 [371]
Heat of polymerization: -186 cal/g [371]
Reid vapor pressure: 1.4 psia [371]
TOXICITY
NIOSH REGISTRY NUMBER: AT0700000
TOXICITY:
typ. dose mode specie amount units other
TCLo ihl hmn 50 ppm
LD50 orl rat 800 mg/kg
LD50 skn rbt 1834 mg/kg
LDLo skn rat 1800 mg/kg
LD50 ipr rat 450 mg/kg
LD50 orl mus 1799 mg/kg
LC50 ihl mus 16200 mg/m3
LD50 ipr mus 599 mg/kg
LD50 orl rbt 400 mg/kg
LCLo ihl rbt 1204 ppm/7H
LCLo ihl gpg 1204 ppm/7H
LC50 ihl rat 2180 ppm/4H
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion and inhalation. Moderately toxic by skin contact and
intraperitoneal routes. A suspected human carcinogen. An experimental
carcinogen. Human systemic effects by inhalation. A skin and eye
irritant. Oral administration of 0.42 gram or more per kg of body weight
in rabbits resulted in fatal poisoning. A substance which migrates to
food from packaging materials.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 103 gm/kg/2Y-I
TDLo: orl-rat 51500 mg/kg/2Y-I
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC possible human carcinogen (Group 2B) [015,610]
Status: NTP Carcinogenesis Studies (Gavage); Positive: Male and Female Rat,
Male and Female Mouse [620]
NTP anticipated human carcinogen [610]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ------------ -----------------
mnt-mus-ipr 225 mg/kg | cyt-ham:lng 9800 ug/L
msc-mus:lym 20 mg/L | mma-mus:lym 20 mg/L
cyt-mus:lym 20 mg/L | mma-sat 100 ug/plate
cyt-ham:ovr 299 mg/L | sce-ham:ovr 150 mg/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 25 ppm (skin) [610]
Final Limit: PEL-TWA 5 ppm (skin); STEL 25 ppm [610]
ACGIH: TLV-TWA 5 ppm, STEL 25 ppm, with a notice of intent to change to a
STEL of 15 ppm and ACGIH suspected human carcinogen [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 3
Reactivity (R): 2
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R2: Materials which are normally unstable and readily undergo violent
chemical change but do not detonate (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rat 1204 ppm/14H-I
eye-mky 1204 ppm/15H-I
skn-rbt 500 mg open MLD
skn-rbt 10 mg/24H MLD
eye-rbt 45 mg MLD
eye-rbt 1204 ppm/7H
eye-gpg 1204 ppm/7H
Review: Toxicology Review
Standards and Regulations: DOT-Hazard: Flammable liquid; Label: Flammable
liquid
Status: NIOSH Analytical Methods: see Esters I, 1450
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Section 8(e) Status Report 8EHQ-1282-0467
EPA TSCA Section 8(e) Status Report 8EHQ-0879-0250
EPA TSCA Section 8(e) Status Report 8EHQ-1078-0250
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, June 1988
Meets criteria for proposed OSHA Medical Records Rule
IDLH Level: 2000 ppm [058,371]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Ethyl acrylate, inhibited
UN/ID NUMBER: UN1917
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 305, Y305 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 307 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used in the manufacturing of acrylic resins for use in
paint formulations, industrial coatings and latexes, in the manufacturing of
plastics such as ethylene ethyl acrylate and in the manufacturing of poly-
acrylate elastomers and acrylic rubber. It is also used in the forming of
denture materials, water emulsion vehicle for paints, textiles and paper coat-
ings, leather finishes, resins or adhesives and lends flexibility to hard
films.
COMMENTS:
Inhibited with 15 ppm hydroquinone monomethyl ether.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion, inhalation or skin absorption. It
can be absorbed through the skin. It is a lachrymator and an irritant of the
skin, eyes, mucous membranes and upper respiratory tract [269]. It is cor-
rosive [058]. The vapor is heavier than air and may travel a considerable
distance to a source of ignition and flash back [058]. When heated to
decomposition it emits smoke and acrid fumes of carbon dioxide and carbon
monoxide [043,269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
PVA Edmont 29-250 0.79 mm 480 min
Butyl rubber North B-174 0.91 mm 480 min
PVC Edmont 34-100 0.18 mm 2 min
Latex Ackwell 5-109 0.15 mm 1 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
chemical cartride respirator equipped with the appropriate organic vapor
cartridges. If that is not available, a half face respirator similarly
equipped plus airtight goggles can be substituted. However, please note
that half face respirators provide a substantially lower level of protection
than do full face respirators.
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical in an explosion-proof refrigerator, and
keep it away from all oxidizing materials. It should be protected from
exposure to light and moisture. STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being
aspirated into the victim's lungs during vomiting which increases the medical
problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the skin,
eyes, mucous membranes, lungs and upper respiratory tract [269]. It may also
cause irritation of the mouth, stomach and throat. Other symptoms include pos-
sible burns of the eyes (damage irreversible), injury to the skin including
reddening and swelling, skin sensitization (allergic reaction), dizziness,
labored breathing and nervousness [058]. Central nervous system effects and
kidney, liver and heart damage have been reported [301]. Other symptoms
include conjunctivitis, lachrymation and chronic lung disease [107]. Inhala-
tion of high concentrations can cause rapid breathing, headache, nausea,
pulmonary edema, lethargy, nose irritation, convulsions and death [151]. It
may also cause chest pain [269]. Loss of consciousness has been reported
[371]. It may also cause shortness of breath [051]. Other symptoms include
coughing, abdominal pain, vomiting, dermatitis and blurred vision. Persons
with pre-existing skin disorders, eye problems, or impaired liver, kidney or
respiratory function may be more susceptible to the effects of this chemical
[058]. It may also cause gastrointestinal tract irritation [421,430].
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