NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001668
CAS NUMBER: 141-78-6
BASE CHEMICAL NAME: ETHYLACETATE
PRIMARY NAME: ETHYL ACETATE
CHEMICAL FORMULA: C4H8O2
STRUCTURAL FORMULA: CH3COOCH2CH3
WLN: 2OV1
SYNONYMS:
ACETIC ACID, ETHYL ESTER
ACETIC ETHER
ACETOXYETHANE
ETHYL ACETIC ESTER
ETHYL ETHANOATE
VINEGAR NAPHTHA
ACETIDIN
RCRA WASTE NUMBER U112
UN 1173
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear, colorless, mobile liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 88.11
SPECIFIC GRAVITY: 0.9003 @ 20/4 C [016,047,071]
DENSITY: 0.8945 g/mL [043,062]
MP (DEG C): -83.6 C [016,043,047,071]
BP (DEG C): 77 C [031,058,346,451]
SOLUBILITIES:
WATER : 50-100 mg/mL @ 21 C (RAD)
DMSO : >=100 mg/mL @ 21 C (RAD)
95% ETHANOL : >=100 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [016,031,062,295]
Benzene: Soluble [016,047]
Ether: Soluble [031,205,295,421]
Chloroform: Soluble [031,205,295,421]
Most organic solvents: Miscible [029]
VOLATILITY:
Vapor pressure: 73 mm Hg @ 20 C [058,062]; 100 mm Hg @ 27 C [038,043,051]
Vapor density : 3.04 [031,043,055,071]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of -4 C (24 F) [043,295,371,451]. It
is flammable. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. The autoignition tempera-
ture is 426 C (800 F) [031,062,421,451].
UEL: 11.5% [031,036,421,451] LEL: 2.0% [058,451]
REACTIVITY:
This chemical may ignite or explode with lithium aluminum hydride [029,
036,066,269]. It may also ignite with potassium tert-butoxide [036,043,066].
It is incompatible with nitrates, strong alkalies and strong acids [102,269,
346]. It will attack some forms of plastics, rubber and coatings [102]. It
is incompatible with oxidizers such as hydrogen peroxide, nitric acid, per-
chloric acid and chromium trioxide [058]. Violent reactions occur with chloro-
sulfonic acid [043,451].
STABILITY:
This chemical is slowly hydrolyzed by moisture [029,031,269]. It
is also sensitive to heat [058,071,102,269]. On prolonged storage, materials
containing similar functional groups have formed explosive peroxides [058].
Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be
stable for 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Pleasant, fruity odor [071]
Odor threshold: 50 ppm [071,421]
Refractive index: 1.3723 @ 20 C [016,047]
log P octanol: 0.66-0.73 [055]
Critical temperature: 250 C [371]
Critical pressure: 38 atmospheres [371]
Liquid surface tension: 24 dynes/cm [371]
Evaporation rate (butyl acetate = 1): 4.5 [058]
Latent heat of vaporization: 87.6 cal/g [371]
Heat of combustion: -5816 cal/g [371]
Specific gravity: 0.9019 @ 20/20 C [058]
100% Volatile by volume [058]
Floats on water [058]
TOXICITY
NIOSH REGISTRY NUMBER: AH5425000
TOXICITY:
typ. dose mode specie amount units other
LCLo ihl cat 61 gm/m3
LCLo ihl gpg 77 mg/m3/1H
TCLo ihl hmn 400 ppm
LC50 ihl mus 45 gm/m3/2H
LC50 ihl rat 1600 ppm/8H
LD50 ipr mus 709 mg/kg
LD50 orl gpg 5500 mg/kg
LD50 orl mus 4100 mg/kg
LD50 orl rat 5620 mg/kg
LD50 orl rbt 4935 mg/kg
LD50 scu cat 3000 mg/kg
LD50 scu gpg 3000 mg/kg
LDLo scu rat 5000 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately irritating to the eyes, mucous membranes, gums and respiratory
tract. Prolonged inhalation can cause renal or hepatic damage. Pro-
longed contact can cause conjunctival irritation and corneal clouding.
Poison by inhalation. Moderately toxic by intraperitoneal route. Mildly
toxic by ingestion. Mutagenic data.
CARCINOGENICITY: Not available
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 400 ppm [015,327,545,610]
Final Limit: PEL-TWA 400 ppm [015,545,610]
ACGIH: TLV-TWA 400 ppm [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 1
Flammability (F): 3
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-hmn 400 ppm
Review: Toxicology Review
Standards and Regulations: DOT-Hazard: Flammable liquid; Label: Flammable
liquid
Status: EPA Genetox Program 1988, Inconclusive: B subtilis rec assay
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, September 1989
IDLH value: 10000 ppm [058]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Ethyl acetate
UN/ID NUMBER: UN1173
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 305, Y305 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 307 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used in artificial fruit essences and as a solvent
for varnishes, aeroplane dopes, coatings, plastics, lacquers, nitrocellulose,
smokeless powders, organic synthesis and pharmaceuticals. It is used as an
insect fumigant and in the manufacture of artificial leather, photographic
film and plates, artificial silks, perfumes and cleaning textiles. It is
also a synthetic flavoring substance and adjuvant.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical is toxic by inhalation, ingestion or skin absorption
[062,071,269]. It is an irritant of the skin, eyes, mucous membranes and
respiratory tract. The vapor is heavier than air and can travel a considerable
distance to a source of ignition and flash back [058]. When heated to decom-
position it emits acrid smoke, irritating fumes and toxic fumes of carbon
monoxide and carbon dioxide [043,058,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
Butyl rubber North B-174 0.64 mm 420 min
Nitrile North LA-142G 0.36 mm 8 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
chemical cartride respirator equipped with the appropriate organic vapor
cartridges. If that is not available, a half face respirator similarly
equipped plus airtight goggles can be substituted. However, please note
that half face respirators provide a substantially lower level of protection
than do full face respirators.
OTHER: Not available
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container under an
inert atmosphere, and store it in an explosion-proof refrigerator. STORE
AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being
aspirated into the victim's lungs during vomiting which increases the medical
problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the eyes,
mucous membranes, gums and respiratory tract [043,071]. Irritation of the
nasal passages and throat may occur [058]. Skin irritation may also occur
[062,269]. Prolonged contact may cause corneal clouding. Prolonged inhalation
can cause renal or hepatic damage [043]. Prolonged inhalation may also cause
damage to the lungs and heart [099]. Other symptoms include gastrointestinal
disturbances, nausea, headache and vomiting [269]. Exposure may cause nar-
cosis and dermatitis [346]. It may also cause drowsiness, unconsciousness
and sleepiness. High concentrations can cause stupor. Repeated or prolonged
contact can cause drying of the skin and cracking [058]. Central nervous
system depression may occur [295]. Chronic exposure may lead to anemia,
leucocytosis, cloudy swelling and fatty degeneration of the viscera [043,071].
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