NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
SODIUM DIETHYLDITHIOCARBAMATE
|
IDENTIFIERS
CATALOG ID NUMBER: 000679
CAS NUMBER: 148-18-5
BASE CHEMICAL NAME: SODIUMDIETHYLDITHIOCARBAMATE
PRIMARY NAME: SODIUM DIETHYLDITHIOCARBAMATE
CHEMICAL FORMULA: C5H10NNaS2
STRUCTURAL FORMULA: (C2H5)2NCS2Na
WLN: SUYSHN2&2 &-NA-
SYNONYMS:
DIETHYLDITHIOCARBAMIC ACID, SODIUM SALT
DIETHYLCARBAMODITHIOIC ACID, SODIUM SALT
DIETHYLDITHIOCARBAMATE SODIUM
DIETHYLDITHIOCARBAMIC ACID SODIUM
DIETHYL SODIUM DITHIOCARBAMATE
SODIUM N,N-DIETHYLDITHIOCARBAMATE
SODIUM SALT OF N,N-DIETHYLDITHIOCARBAMIC ACID
DITHIOCARB
DITHIOCARBAMATE
DEDC
DEDK
SODIUM DEDT
USAF EK-2596
CUPRAL
DDC
NCI-C02835
THIOCARB
CARBAMIC ACID, DIETHYLDITHIO-, SODIUM SALT
CARBAMODITHIOIC ACID, DIETHYL-, SODIUM SALT
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White, slightly brown or slightly pink
crystals
REPOSITORY: White crystalline solid
MOLECULAR WEIGHT: 171.27
SPECIFIC GRAVITY: 1.1 @ 20/20 C [043,058]
DENSITY: Not available
MP (DEG C): 95 C [043,058]
BP (DEG C): Not available
SOLUBILITIES:
WATER : >=100 mg/mL @ 14 C (RAD)
DMSO : >=100 mg/mL @ 14 C (RAD)
95% ETHANOL : 50-100 mg/mL @ 14 C (RAD)
METHANOL : Not available
ACETONE : 50-100 mg/mL @ 14 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [295]
VOLATILITY:
Vapor pressure: Not available
Vapor density : 5.9 [043,058]
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with a
dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [058].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizers [058]. The addition
of an acid to the aqueous solution produces a white turbidity [058].
STABILITY:
This chemical is stable under normal laboratory conditions [058].
Aqueous solutions slowly decompose [395]. UV spectrophotometric stability
screening indicates that solutions of this chemical in acetone are stable
for at least 24 hours (RAD).
OTHER PHYSICAL DATA:
Odorless [058]
Lambda max: 257 nm, 290 nm (E = 700, 760) [395]
TOXICITY
NIOSH REGISTRY NUMBER: EZ6475000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1500 mg/kg
LD50 ipr rat 1250 mg/kg
LD50 orl mus 1500 mg/kg
LD50 ipr mus 1302 mg/kg
LD50 orl rbt 500 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately toxic by ingestion, intraperitoneal and subcutaneous routes.
An experimental neoplastigen, teratogen and possible carcinogen.
Experimental reproductive effects. Human mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 76 gm/kg/78W-I
Review: IARC Cancer Review: Animal Inadequate Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [015,395,610]
Status: NCI Carcinogenesis Bioassay (Feed); Negative: Male and Female Rat,
Male and Female Mouse [620]
MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
oms-omi 100 umol/L | dnd-hmn:hla 100 umol/L
cyt-rat-orl 5200 mg/kg |
TERATOGENICITY: See RTECS printout for most current data
Reproductive Effects Data:
TDLo: scu-mus 1935 mg/kg (6-14D preg)
TDLo: ipr-dog 100 mg/kg (1D male)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review-2
Status: EPA TSCA Chemical Inventory, 1989
EPA Genetox Program 1988, Negative: Carcinogenicity-mouse/rat
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a pesticide, fungicide and chelating agent
with strong affinity for mercury, copper, nickel and zinc. It is used in
the evaluation of T-cell deficient diseases, in the inhibition of superoxide
dismutase in mice and of cisplatin nephrotoxicity in rats, in AIDS-related
complex, in immunopharmacology and in cancer immunotherapy. It has clinical
use in acute nickel carbonyl, cadmium and thallium poisoning. It is used in
colorimetric determination of small quantities of copper and for its separation
from other metals. It is also used as a latex accelerator in rubber processing
and as a chemical intermediate in the production of other diethyldithiocarba-
mate metal salts, such as zince selenium and tellurium salts.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical may be harmful if swallowed or inhaled [058]. When heated
to decomposition it emits very toxic fumes of nitrogen oxides, sulfur oxides
and sodium oxide [043,058].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-161 0.63 mm 480 min
Neoprene Edmont 29-870 0.50 mm 480 min
PVC Edmont 34-100 0.20 mm 480 min
Natural rubber Ackwell 5-109 0.15 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material under ambient temperatures and keep it
away from oxidizing materials.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water, then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this chemical include irritation of the eyes.
Continued exposure may cause mild skin irritation. The dusts of this com-
pound are caustic to the mucous membranes. This compound is also caustic
to the digestive tract [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. EZ6475000.
July 23, 1990.
[033] Budavari, Susan, Ed. The Merck Index. 11th Ed. Merck and Co., Inc.
Rahway, NJ. 1989. p. 533, #3384.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. III, p. 3062, #SGJ000.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. June/July 1990.
#5846-099, E-05.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. p. 392, #1054-Y.
[395] International Agency for Research on Cancer, World Health
Organization. IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. Vol. 12, pp. 217-
223; Supplement 7, p. 71.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 60.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
-------------------------------------------------------------