NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002245
CAS NUMBER: 25265-71-8
BASE CHEMICAL NAME: DIPROPYLENEGLYCOL
PRIMARY NAME: DIPROPYLENE GLYCOL
CHEMICAL FORMULA: C6H14O3
STRUCTURAL FORMULA: Not printable
WLN: QY1&101YQ1
SYNONYMS:
PROPANOL, OXYBIS-
OXYBISPROPANOL
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless, slightly viscous liquid
REPOSITORY: Clear, colorless liquid
MOLECULAR WEIGHT: 134.18
SPECIFIC GRAVITY: 1.0224 @ 20/20 C [016,047]
DENSITY: 1.02-1.03 g/mL [295]
MP (DEG C): -40 C [053]
BP (DEG C): 229-232 C [016,047,053]
SOLUBILITIES:
WATER : >=100 mg/mL @ 24 C (RAD)
DMSO : >=100 mg/mL @ 24 C (RAD)
95% ETHANOL : >=100 mg/mL @ 24 C (RAD)
METHANOL : Soluble [053]
ACETONE : >=100 mg/mL @ 24 C (RAD)
TOLUENE : Soluble [053,062]
OTHER SOLVENTS:
Alcohol: Soluble [016,053]
Chloroform: Miscible [295]
Ether: Miscible [295]
VOLATILITY:
Vapor pressure: 1 mm Hg @ 73.8 C [038,043]; 760 mm Hg @ 231.8 C [038]
Vapor density : 4.63 [053,055,058,451]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 138 C (280 F) [043,062,269,371]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be used
[058,269,371,451]
UEL: 12.6% [053] LEL: 2.2% [371,900]
REACTIVITY:
This chemical can react vigorously with acids and oxidizing materials
[058]. It is incompatible with strong bases [269]. It is incompatible with
peroxides [053].
STABILITY:
This chemical is hygroscopic [053]. Solutions of this chemical in
water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal
lab conditions (RAD).
OTHER PHYSICAL DATA:
Specific gravity: 1.0202 @ 24.8/23.4 C [901]
Supercools [055]
Boiling point: 231.1 C @ 746.7 mm Hg [901]
Vapor pressure: 5 mm Hg @ 102.1 C, 10 mm Hg @ 116.2 C, 20 mm Hg @ 131.3 C,
40 mm Hg @ 147.4 C, 60 mm Hg @ 156.6 C, 100 mm Hg @ 169.9 C, 200 mm Hg
@ 189.9 C, 400 mm Hg @ 210.5 C [038]
Heat of combustion: -6470 cal/g [371]
Latent heat of vaporization: 96 cal/g [371]
Log Poctanol: -1.17/-1.23 (calculated) [055]
Coefficient of expansion: 0.00073 @ 20 C [062]
Viscosity: 1.07 poise @ 20 C [062]
Refractive index: 1.0224 @ 20 C [053]
Critical temperature: 382 C [371]
Critical pressure: 36 atm [371]
Heat of solution: -7 cal/g [371]
Nearly odorless [043,371]
TOXICITY
NIOSH REGISTRY NUMBER: UB8765000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 14850 mg/kg
LD50 ipr rat 10 gm/kg
LD50 ivn rat 5800 mg/kg
LD50 ipr mus 4494 mg/kg
LD50 ivn dog 11500 mg/kg
LD50 orl gpg 17600 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Mildly toxic by ingestion. A skin and eye irritant. Mutagenic data.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies: selected, July 1989
MUTATION DATA: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 0
Flammability (F): 1
Reactivity (R): 0
H0: Materials which on exposure under fire conditions would offer no
hazard beyond that of ordinary combustible material (see NFPA for
details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 510 mg
skn-rbt 500 mg/24H MLD
Review: Toxicology Review
Status: EPA TSCA Chemical Inventory, 1986.
EPA TSCA Test Submission (TSCATS) Data Base, September 1989
Adult fatal dose: 14,000 mg/kg [301]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This chemical is used in polyester and alkyd resins, reinforced plastics,
plasticizers, solvents, fragrances, lacquer, paint, printing ink and shellac
varnish. It is also used in the manufacture of nitrocellulose solvent.
COMMENTS:
This compound is a mixture of three isomers, 1,1'-Oxybis(2-propanol),
2-(2-Hydroxypropoxy)-1-propanol and 2,2'-Oxybis(1-propanol) [901]. The
toxicity data listed is for 1,1'-Oxybis(2-propanol).
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this chemical emits acrid smoke and irritat-
ing fumes [043,053]. Decomposition products include carbon monoxide, carbon
dioxide, aldehydes and acids [058,269,900]. This chemical may be readily
absorbed through the skin [269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Nitrile Comasec Comatril 0.63 mm 240 min
Neoprene Edmont Neox 0.43 mm 240 min
PE/EVOH/PE Safety 4-4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and keep it away from oxidizing materials. If possible, it would be prudent
to store this compound under inert atmosphere.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include skin irritation, nausea,
headache and vomiting [269]. It can cause kidney and liver damage [151,301].
Eye irritation may also occur [058,269,371,900]. Other symptoms may include
gastrointestinal irritation, sore throat, coughing, difficult breathing and
fatigue [053].
SOURCES
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