NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001561
CAS NUMBER: 26471-62-5
BASE CHEMICAL NAME: TOLUENEDIISOCYANATE
PRIMARY NAME: TOLUENE DIISOCYANATE
CHEMICAL FORMULA: C9H6N2O2
STRUCTURAL FORMULA: CH3C6H3(NCO)2
WLN: Not available
SYNONYMS:
TOLYLENE DIISOCYANATE
DIISOCYANATOTOLUENE
ISOCYANIC ACID, METHYL-M-PHENYLENE ESTER
1,3-DIISOCYANATOMETHYLBENZENE
DIISOCYANATOMETHYLBENZENE
METHYLPHENYLENE ISOCYANATE
TOLYLENE ISOCYANATE
ISOCYANIC ACID, METHYL PHENYLENE ESTER
METHYL-META-PHENYLENE DIISOCYANATE
DESMODUR T100
NIAX ISOCYANATE TDI
TDI
UN 2078
MONDUR-TD
MONDUR-TD-80
NACCONATE-100
RUBINATE TDI
RUBINATE TDI 80/20
T 100
TDI-80
TDI-80-20
HYLENE-T
RCRA WASTE NUMBER U223
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Water-white to pale yellow liquid
REPOSITORY: Light yellow, hazy liquid
MOLECULAR WEIGHT: 174.16
SPECIFIC GRAVITY: 1.22 @ 25/25 C [053,058,371,395]
DENSITY: Not available
MP (DEG C): 19.5-21.5 C [031,043,395]
BP (DEG C): 251 C [031,043,058,395]
SOLUBILITIES:
WATER : Reacts [031,036,058,371]
DMSO : >=100 mg/mL @ 21.5 C (RAD)
95% ETHANOL : Reacts [043,058,269,395]
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Carbon tetrachloride: Miscible [043,395]
Chlorobenzene: Miscible [043,395]
Olive oil: Miscible [043,395]
Kerosene: Miscible [043,053,395]
Ether: Miscible [031,043,205,395]
Benzene: Miscible [031,043,205,395]
Other organic solvents: Soluble [395]
Diglycol monomethyl ether: Miscible [031,395]
Alcohol (decomp.): Miscible [043]
VOLATILITY:
Vapor pressure: 0.025 mm Hg @ 25 C [058,421]; 1 mm Hg @ 80 C [055]
Vapor density : 6.0 [043,055,058,395]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 121 C (250 F) [205,269,275]. It is
combustible. Fires involving this material can be controlled with a carbon
dioxide, dry chemical or Halon extinguisher. The autoignition temperature is
>149 C (>300 F) [371].
UEL: 9.5% [043,053,058,371] LEL: 0.9% [043,053,058,371]
REACTIVITY:
This compound is incompatible with strong oxidizers, acids and amines
[395]. It may polymerize vigorously on contact with bases and acyl chlorides
[036,043,066]. It reacts with water to release carbon dioxide [031,036,058,
371]. It is incompatible with alcohols [058,269,395]. It can react vigorously
with compounds containing active hydrogen [053,395]. It will cause some corro-
sion to copper alloys and aluminum [058]. Concentrated alkaline compounds like
NaOH or tertiary amines may cause run-away polymerization [031].
STABILITY:
This chemical is sensitive to moisture and heat [058,395]. It is also
sensitive to light [031,395]. Solutions of this chemical in acetone should
be stable for 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Refractive index: 1.5689 @ 20 C [205,269]
Sharp pungent odor [036,058,395,421]
Vapor pressure: 0.01 mm Hg @ 20 C [053,055,395]
Boiling point: 115-120 C @ 10 mm Hg [269,275]; 124-126 C @ 18 mm Hg [026,395]
Specific gravity: 1.2244 @ 20/4 C [031,043,047,205]; 1.22 @ 25/15 C [395]
Odor threshold: >0.005 ppm [058]
Storage in polyethylene containers may caue the evolution of gas due to
diffusion of moisture in the containers [036,043,066]
TOXICITY
NIOSH REGISTRY NUMBER: NQ9490000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 4130 mg/kg
LCLo ihl rat 600 ppm/6H
LD50 orl mus 1950 mg/kg
LC50 ihl gpg 12700 ppb/4H
LC50 ihl mus 9700 ppb/4H
LC50 ihl rbt 11 ppm/4H
AQTX/TLM96: 10-1 ppm
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, inhalation and intravenous routes. An experimental
carcinogen. May be a human carcinogen. Mutagenic data. A common air
contaminant.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 63 gm/kg/2Y-I
TDLo: orl-rat 31800 mg/kg/2Y-I
TD : orl-rat 63600 mg/kg/2Y-I
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC possible human carcinogen (Group 2B) [610]
Status: NTP Fourth Annual Report on Carcinogens, 1984
NTP Carcinogenesis Studies (Gavage); Positive: Male and Female Rat,
Female Mouse [620]
NTP Carcinogenesis Studies (Gavage); Negative: Male Mouse [620]
NTP anticipated human carcinogen [610]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mma-sat 100 ug/plate | cyt-hmn:lym 92 mg/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-Ceiling Limit 0.02 ppm [610]
Final Limit: PEL-TWA 0.005 ppm; STEL 0.02 ppm [610]
ACGIH: TLV-TWA 0.005 ppm; STEL 0.02 ppm [415,421,610]
NIOSH Criteria Document: Recommended Exposure Limit to this compound-air:
TWA 0.005 ppm; Ceiling Limit 0.02 ppm/10M [015]
NFPA Hazard Rating: Health (H): 3
Flammability (F): 1
Reactivity (R): 1
H3: Materials extremely hazardous to health but areas may be entered
with extreme care (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R1: Materials which are normally stable but which may become unstable at
elevated temperatures and pressures or which may react with water with
some release of energy but not violently (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg open SEV
Standards and Regulations: DOT-Hazard: Poison B; Label: Poison
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, March 1988
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Toluene diisocyanate
UN/ID NUMBER: UN2078
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 609, Y609 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 611 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used to manufacture polyurethane foams used in furniture,
packaging, insulation and boat building, to manufacture polyurethane coatings
used on leather, wire, tank linings and masonry, and to manufacture other elas-
tomers used in adhesives, films, linings, abrasive wheels and other mechanical
items.
COMMENTS:
This compound is a mixture of the 2,4- isomer (89.3%) and the 2,6- isomer
(10.7%). There are no important recognized toxicological distinctions between
the 2,4- and the 2,6- isomers. Most information for this compound, including
THR and ACGIH data, is taken from data on the 2,4- isomer.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical is highly toxic by inhalation and ingestion [026,036,
269]. It is also highly toxic by skin contact [026]. It is an irritant
of the skin, eyes, mucous membranes and respiratory tract [058,269,421].
It is also a lacrimator [052,269,275,421]. When heated to decomposition
it emits very toxic fumes of carbon monoxide, carbon dioxide, hydrogen
cyanide and nitrogen oxides [058,269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
PVA Edmont 25-545 0.23 mm 960 min
Viton North F-091 0.25 mm 960 min
Butyl rubber North B-174 0.41 mm 480 min
Nitrile North LA-1426 0.33 mm 195 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
SPILLS AND LEAKAGE:
If you should spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION,
then use absorbent paper to pick up all liquid spill material. Your contamina-
ted clothing and absorbent paper should be sealed in a vapor-tight plastic bag
for eventual disposal. Solvent wash all contaminated surfaces with acetone
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the
skin, eyes and respiratory system [036,151,346,371]. It may cause bronchial
asthma [031,052,058,151]. It may also cause bronchitis and pulmonary edema
[058,346,371,421]. Other symptoms may include nausea, vomiting and abdominal
pain [058,346,421]. Exposure may cause an asthmatic reaction with wheezing,
dyspnea and cough [058,269,346,421]. Some decrease in lung function in the
absence of symptoms has been observed after long periods of exposure [058,
346,371]. Eosinophilia has been reported [052,151]. It may cause sore throat,
runny nose, diarrhea and bronchial spasm. High concentrations are destructive
to tissues of the skin, eyes, mucous membranes, upper respiratory tract and
digestive tract. Chemical or hypersensitive pneumonia may occur with flu-like
symptoms (e.g. fever, chills) [058]. Irritation of the lungs may occur [371].
Exposure may also cause laryngitis, shortness of breath and headache [269].
Chest discomfort, including tightness and congestion, occurs [058,421]. Insom-
nia has occured [421]. Death may result if inhaled, swallowed or absorbed
through the skin [269].
Skin contact may result in severe dermatitis [043,036,052]. If the liquid
is allowed to remain in contact with the skin, it may produce redness, swell-
ing and blistering [058,346]. It may also cause rashes and scaling. Skin
sensitization can occur [058]. Allergic eczema may also occur [031].
Eye contact may cause severe irritation resulting in permanent damage
if left untreated [058,346]. It may cause keratitis and conjunctivitis [099].
Eye contact may also cause lacrimation, smarting, burning and a prickling sen-
sation [421].
Ingestion may cause burns of the mouth and stomach [346]. It may also
have a corrosive effect on the stomach and esophagus [052,058]. Gastrointes-
tinal irritation may occur [151].
Medical conditions aggravated by exposure to this compound include asthma,
bronchitis, emphysema, bronchial hyperactivity, skin allergies and eczema
[058].
SOURCES
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