NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001159
CAS NUMBER: 316-42-7
BASE CHEMICAL NAME: EMETINEHYDROCHLORIDE
PRIMARY NAME: EMETINE HYDROCHLORIDE
CHEMICAL FORMULA: C29H40N2O4.2HCl
STRUCTURAL FORMULA:
WLN: T B666 GNTT&J D1- BT66 CMT&J HO1 IO1& E2 LO1 MO1 &GH &GH
SYNONYMS:
AMEBICIDE
(-)-EMETINE DIHYDROCHLORIDE
(-)-EMETINE HYDROCHLORIDE
L-EMETINE DIHYDROCHLORIDE
L-EMETINE HYDROCHLORIDE
EMETINE DIHYDROCHLORIDE
NSC-33669
6',7',10,11-Tetramethoxyemetan dihydrochloride
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: White powder
MOLECULAR WEIGHT: 679.69
SPECIFIC GRAVITY: Not available
DENSITY:Not available
MP (DEG C): 235-270 C (Decomposes)
BP (DEG C): Not available
SOLUBILITIES:
WATER : Soluble (>=10 mg/ml @ 21 C) (RAD)
DMSO : Soluble (>=10 mg/ml @ 21 C) (RAD)
95% ETHANOL : Soluble (>=10 mg/ml @ 21 C) (RAD)
METHANOL : Not available
ACETONE : Not available
TOLUENE : Not available
OTHER SOLVENTS: Not available
ETHER : Insoluble (CRC)
VOLATILITY : Not available
FLAMMABILITY(FLASH POINT):
The flash point of this chemical has not been determined, but it is probably
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide, foam or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY: Neat material and solutions turn yellow on exposure to light and
heat; sensitive to light and heat.
OTHER PHYSICAL DATA: Contains water of crystallization varying from 3 to 8 H2O
TOXICITY
NIOSH REGISTRY NUMBER: JY5250000
TOXICITY:
typ. dose mode specie amount unit other
LD50 ipr rat 17 mg/kg
LD50 orl mus 44 mg/kg
LD50 ipr mus 62 mg/kg
LD50 scu mus 45 mg/kg
LDLo orl cat 15 mg/kg
LDLo orl rbt 15 mg/kg
LDLo scu rbt 20 mg/kg
LDLo ivn rbt 2500 ug/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION: Not available
CARCINOGENICITY:
Status: NCI Carcinogenesis Bioassay (IP/IJ); Inadequate Study: Male and Female
Rat, Male and Female Mouse [620]
MUTAGENICITY: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-hmn 3250 ug
Status: Reported in EPA TSCA Inventory, 1980
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Poisonous solids, n.o.s.
(Emetine hydrochloride)
UN/ID NUMBER: UN2811
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: I
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 606 MAXIMUM QUANTITY: 5 kg
CARGO : PKG. INSTR.: 607 MAXIMUM QUANTITY: 50 kg
SPECIAL PROVISIONS: A5
USES: Antiamebic; (VET): Has been used as an antiamebic and for lungworm infec
COMMENTS:
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
Irritant.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this material from exposure to light,
and store it in a refrigerator.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water,then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a strong soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center.
Generally, the induction of vomiting is NOT recommended outside of a
physician's care due to the risk of aspirating the chemical into the victim's
lungs. However, if the victim is conscious and not convulsing and if medical
help is not readily available, consider the risk of inducing vomiting because
of the high toxicity of the chemical ingested. Ipecac syrup or salt water may
be used in such an emergency. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms associated with this material include lesions of the heart, kidney,
liver, intestinal tract and skeletal muscle. This compound may also cause
diarrhea, cramping and abdominal pain as well as marked prostration and nausea
FIREFIGHTING: Not available
SOURCES
SOURCES:
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1982. p.528, no. 21,928-2.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. Not listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. Not listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 408.
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. Not listed.
Sax, N.I. Dangerous Properties of Industrial Materials. 5th Ed.
Van Nostrand Reinhold. New York. 1979. Not listed.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. p. 468, no. 3511.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 60th Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-284, no. e40.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic
Effects of Chemical Substances. DHEW (NIOSH) Publication
No. 79-100. National Institute for Occupational Safety
and Health. Cincinnati, OH. 1979. JY5250000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxxiv.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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