NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001527
CAS NUMBER: 529-20-4
BASE CHEMICAL NAME: TOLUALDEHYDE,O-
PRIMARY NAME: O-TOLUALDEHYDE
CHEMICAL FORMULA: C8H8O
STRUCTURAL FORMULA: CH3C6H4CHO
WLN: VHR B1
SYNONYMS:
2-METHYLBENZALDEHYDE
O-METHYLBENZALDEHYDE
O-TOLUIC ALDEHYDE
O-TOLUYLALDEHYDE
O-TOLYLALDEHYDE
2-TOLUALDEHYDE
2-FORMYLTOLUENE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Liquid
REPOSITORY: Clear liquid
MOLECULAR WEIGHT: 120.15
SPECIFIC GRAVITY: 1.0386 @ 19/4 C [017,031,047,205]
DENSITY: Not available
MP (DEG C): Not available
BP (DEG C): 200-202 C @ 760 mm Hg [031,107,205]
SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Benzene: >10% [047]
Ether: >10% [047]
Chloroform: Soluble [017]
VOLATILITY:
Vapor pressure: 1.0 mm Hg @ 60 C; 8.0 mm Hg @ 73 C; 26.0 mm Hg @ 97 C [601]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 67 C (153 F) [205,269,275]. It is
combustible. Fires involving this material can be controlled with a
dry chemical, carbon dioxide or Halon extinguisher. A water spray may
also be used [269].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong bases and strong reducing agents
[107,269]. It is also incompatible with strong oxidizers [269]. It may
react with ketones, sulfuric acid, nitric acid, caustics and ammonia [107].
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions of
this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Boiling point: 68-72 C @ 6 mm Hg [025,031]; 94 C @ 10 mm Hg [017,047]
Boiling point: 94-96 C @ 15 mm Hg [031]
Refractive index: 1.549 @ 19 C; 1.5472 @ 20 C; 1.5430 @ 25 C
Vapor pressure: 61.0 mm Hg @ 125 C [601]
TOXICITY
NIOSH REGISTRY NUMBER: Not available
TOXICITY:
typ. dose mode specie amount units other
Not available
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Not available
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
Not available |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA: Not available
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
Related compounds are used in perfumes, pharmaceuticals, dyestuff inter-
mediates and flavoring agents.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be harmful by inhalation, ingestion or skin absorption.
It may cause irritation. When heated to decomposition it emits toxic
fumes of carbon monoxide and carbon dioxide [269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PVA Edmont 29-545 0.63 mm 240 min.
Viton North F-091 0.24 mm 120 min.
PE/EOH/PE Safety 4 4H 0.07 mm 240 min.
Unknown North Silvershield 0.01 mm 240 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and keep it away from oxidizing materials.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation [269].
SOURCES
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[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 4, p. 3742, #M-00902.
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[110] Oak Ridge National Laboratory. Environmental Mutagen Information
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[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-496, #m263.
[240] Grayson, Martin, Ed. Kirk-Othmer Encyclopedia of Chemical Technology.
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[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
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p. 1713, #B.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
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1988. p. 1442, #11,755-2.
[601] Safety Consulting Engineers Inc. Vapor Pressure Test Results for
Twelve Materials. Report Number 111053-LR. Safety Consulting
Engineers Inc. Rosemont, IL. August 5, 1988.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
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[620] United States National Toxicology Program. Chemical Status Report.
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