NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000158
CAS NUMBER: 70-34-8
BASE CHEMICAL NAME: DINITROFLUOROBENZENE,2,4-
PRIMARY NAME: 2,4-DINITROFLUOROBENZENE
CHEMICAL FORMULA: C6H3FN2O4
STRUCTURAL FORMULA:
WLN: WNR BF ENW
SYNONYMS:
2,4-DNFB
DNFB
DNP-F
2,4-DINITRO-1-FLUOROBENZENE
SANGER'S REAGENT
1-FLUORO-2,4-DINITROBENZENE
FDNB
1,2,4-FLUORODINITROBENZENE
1,3-DINITRO-4-FLUOROBENZENE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: Literature: Clear, yellow crystals
Repository: Yellow crystalline solid
MOLECULAR WEIGHT: 186.10
SPECIFIC GRAVITY: 1.482 @ 20/4
DENSITY: 1.4718 g/mL @ 84 C
MP (DEG C): 27.5-30.0 C
BP (DEG C): 296 C @ 760 mm Hg ; 178 C @ 25 mm Hg ; 133 C @ 2 mm Hg
SOLUBILITIES:
WATER : 0.1-1.0 mg/mL @ 19.7 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Propylene glycol: Soluble.
ETHER : Soluble.
BENZENE: Soluble.
VOLATILITY : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point > 112 C (235 F). It is probably combustible.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide, foam or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: Reacts with oxidizers.
STABILITY: This chemical is stable under normal laboratory conditions.
OTHER PHYSICAL DATA: Refractive Index : 1.5690 @ 20 C
TOXICITY
NIOSH REGISTRY NUMBER: CZ7800000
TOXICITY:
typ. dose mode specie amount unit other
LDLo orl rat 50 mg/kg
LDLo skn mus 100 mg/kg
LDLo scu mus 100 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR=HIGH via oral and subcutaneous routes. An experimental
carcinogen and mutagen. A powerful irritant and vesicant (causes
blisters).
CARCINOGENICITY:
Tumorigenic Data:
TDLo: skn-mus 240 mg/kg/10D-I
MUTATION DATA:
mmo-sat 500 mmol/L
mma-sat 100 ug/plate
mmo-esc 5 umol/L
dnr-esc 10 ul/well/16H
mrc-smc 320 umol/L
otr-ham:kdy 80 ug/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: Reported in EPA TSCA Inventory, 1980
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This chemical is an alkylating agent. It is used for labeling
terminal amino groups of polypeptides and for characterizing
amines and amino acids.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical is highly toxic, a powerful irritant, and causes blistering.
It caused allergic reactions and dermatitis by skin contact or inhalation.
It can be absorbed through the skin.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material in a refrigerator away from oxidizing
materials.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, you should
dampen the solid spill material with alcohol, then transfer the dampened
material to a suitable container. Use absorbent paper dampened with alcohol
to pick up any remaining material. Seal the absorbent paper, and any of your
clothes, which may be contaminated,in a vapor-tight plastic bag for eventual
disposal. Solvent wash all contaminated surfaces with alcohol followed by
washing with a strong soap and water solution. Do not reenter the contaminate
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation to the eyes,
skin and mucous membranes.
FIREFIGHTING: Not available
SOURCES
SOURCES:
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1982. p. 499.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 374.
Sax, N.I. Dangerous Properties of Industrial Materials. 5th Ed.
Van Nostrand Reinhold. New York. 1979. p. 692.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. p. 540, No. 4057.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982.
Vol. 3, p. 2648, #F-00383; also in Supplement 1, p. 265, #F-10066.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 63rd Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-136, No. 2128.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. CZ7800000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Not listed.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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