NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000595
CAS NUMBER: 7320-37-8
BASE CHEMICAL NAME: EPOXYHEXADECANE,1,2-
PRIMARY NAME: 1,2-EPOXYHEXADECANE
CHEMICAL FORMULA: C16H32O
STRUCTURAL FORMULA:
WLN: T3OTJ B14
SYNONYMS:
HEXADECENE EPOXIDE
TETRADECYL OXIRANE
NCI-C55538
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: White waxy solid or clear colorless liquid
REPOSITORY: White powder
MOLECULAR WEIGHT: 240.48
SPECIFIC GRAVITY: 0.849 @ 20/4 C
DENSITY: 0.85 g/mL
MP (DEG C): 25-27 C (RAD)
BP (DEG C): 270-275 C
SOLUBILITIES:
WATER : Reaction
DMSO : <1 mg/mL @ 18 C (RAD)
95% ETHANOL : Reaction
METHANOL : Not available
ACETONE : 50-100 mg/mL @ 18 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data are not available for this chemical, but it is probably
combustible. Fires involving this compound should be controlled using a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This material reacts with inorganic acids, thiosulfate, carboxylic acids,
hydrogen cyanide, water, amines, aldehydes, alcohols, and caustics. It will
also react with amino, hydroxyl and carboxyl groups.
STABILITY:
The neat compound is sensitive to prolonged exposure to heat. It is also
moisture sensitive.
OTHER PHYSICAL DATA:
Faint pleasant odor
TOXICITY
NIOSH REGISTRY NUMBER: ML9450000
TOXICITY:
typ. dose mode specie amount units other
Not available
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: An experimental equivocal tumorigenic agent.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: skn-mus 53 gm/kg/44W-I
TDLo: unr-mus 240 mg/kg
Status: NTP Carcinogenesis Studies; test completed, April 1985
MUTATION DATA:
test lowest dose | test lowest dose
---------- ---------------- | ---------- ----------------
Not available |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: Reported in EPA TSCA Inventory, 1983
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
Organic synthesis
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This material can cause skin, eye and mucous membrane irritation. When heated
to decomposition it emits acrid smoke and fumes.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture.
SPILLS AND LEAKAGE:
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION,
then you should dampen the solid spill material with acetone and transfer the
dampened material to a suitable container. Use absorbent paper dampened with
acetone to pick up any remaining material. Seal your contaminated clothing
and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with acetone followed by washing with
a soap and water solution. Do not reenter the contaminated area until the
Safety Officer (or other responsible person) has verified that the area has
been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials associated
with this chemical as specified by existing local, state and federal regula-
tions concerning hazardous waste disposal. It is suggested that your
contaminated materials should be destroyed by incineration in a special,
high temperature (>2000 F) chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Exposure to this compound may result in skin irritation which is characterized
by localized lesions, redness, swelling and itching. Chronic symptoms include
loss of body weight, gastric irritation and moderate liver damage. Prolonged
inhalation may cause acute pulmonary edema or chemical pneumonia. It also
causes sensitization.
SOURCES
SOURCES:
Midwest Research Institute. MRI Report for 1,2-Epoxyhexadecane.
Kansas City, MO. April 17, 1979.
Arthur D. Little, Inc. Health and Safety Package for
1,2-Epoxyhexadecane. Arthur D. Little, Inc. Cambridge, MA.
July 26, 1978.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1984. p. 497; #26,021-5.
Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIA, p. 2157.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 1286.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. ML9450000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 108.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
-------------------------------------------------------------