NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001051
CAS NUMBER: 75-12-7
BASE CHEMICAL NAME: FORMAMIDE
PRIMARY NAME: FORMAMIDE
CHEMICAL FORMULA: CH3NO
STRUCTURAL FORMULA: HCONH2
WLN: ZVH
SYNONYMS:
CARBAMALDEHYDE
METHANAMIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless, slightly viscous liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 45.04
SPECIFIC GRAVITY: 1.1334 @ 20/4 C [016,047,205,275]
DENSITY: 1.1334 g/cm3 @ 20 C [016,047,205]
MP (DEG C): 2.5 C [016,025,043,047]
BP (DEG C): 210 C (decomposes) [051,055,058,451]
SOLUBILITIES:
WATER : >=100 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : >=100 mg/mL @ 19 C (RAD)
METHANOL : Miscible [025,031,421]
ACETONE : >=100 mg/mL @ 19 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Miscible [043,205]
Benzene: Very slightly soluble [025,031,205]
Chloroform: Insoluble [025]
Ether: Very slightly soluble [025,031,043,205]
Hexane: Insoluble [025]
Acetic acid: Miscible [031,205,421]
Dioxane: Miscible [031,421]
Ethylene glycol: Miscible [031,421]
Glycol: Miscible [031]
Phenol: Miscible [031]
VOLATILITY:
Vapor pressure: 3 mm Hg @ 30 C [058,421]; 760 mm Hg @ 210.5 C [038]
Vapor density : 1.56 [055]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 154 C (310 F) [031,043,058,451]. It
is combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizers, acids and bases
[269]. It is also incompatible with iodine, pyridine and sulfur trioxide
[058]. It reacts explosively with furfuryl alcohol, H2O2, Tl(NO3)3.H2O,
nitromethane and P2O5 [043]. This compound dissolves casein, glucose, zein,
tannins, starch, lignin, polyvinyl alcohol, cellulose acetate, nylon, the
chlorides of copper, lead, zinc, tin, cobalt, iron, aluminum and nickel, the
acetates of the alkali metals, some inorganic sulfates and nitrates [031].
It attacks copper and brass [058].
STABILITY:
This chemical is hygroscopic [025,043,051,062]. It is sensitive to light
[058]. It hydrolyzes very slowly at room temperature, but hydrolysis is
accelerated by acids and bases at elevated temperatures [421]. Solutions of
this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24
hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Specific gravity: 1.134 @ 20/40 C, 1.1292 @ 25/4 C [043,051]
Boiling point: 70.5 C @ 1 mm Hg, 109.5 C @ 10 mm Hg, 122.5 C @ 20 mm Hg [031]
Boiling point: 147.0 C @ 60 mm Hg, 175.5 C @ 200 mm Hg [031]
Boiling point: 193.5 C @ 400 mm Hg [031]
Vapor pressure: 29.7 mm Hg @ 129.40 [043,051]; 1 mm Hg @ 70.5 C [038]
Vapor pressure: 5 mm Hg @ 96.3 C, 10 mm Hg @ 109.5 C, 20 mm Hg @ 122.5 C [038]
Vapor pressure: 40 mm Hg @ 137.5 C, 60 mm Hg @ 147.0 C [038]
Vapor pressure: 100 mm Hg @ 157.5 C, 200 mm Hg @ 175.5 C [038]
pKa: 0.12 [025]
Dielectric constant: 84 [031]
Surface tension: 58.35 @ 20 C [031]
pH of 0.5M aqueous solution: 7.1 [031,058]
Freezing point: 2.6 C [043,051,421]
UV max: 400-360 nm, 300 nm, 280 nm, 275 nm (A = 0.01, 0.05, 0.20, 1.0) [275]
Odorless [025,031]
Industrial grades have a faint ammonia odor [031,058,346]
Refractive index: 1.44911 @ 15 C, 1.44754 @ 20 C, 1.4170 @ 110 C [031]
Refractive index: 1.40951 @ 130 C [031]
Evaporation rate (butyl acetate = 1): <1 [058]
TOXICITY
NIOSH REGISTRY NUMBER: LQ0525000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 5570 mg/kg
LD50 ipr rat 5700 mg/kg
LD50 unr rat 3 gm/kg
LD50 orl mus 3150 mg/kg
LD50 ipr mus 2450 mg/kg
LD50 ipr gpg 1250 mg/kg
LDLo ivn dog 1500 mg/kg
LDLo skn rbt 6 mg/kg
LDLo scu frg 30 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intravenous route. Moderately toxic by ingestion and
intraperitoneal routes. Mildly toxic by inhalation. A suspected
carcinogen. Mutagenic data.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
oms-nml:oth 500 mmol/L | cyt-nml:oth 500 mmol/L
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 2 gm/kg (7D preg)
TDLo: orl-rat 7980 mg/kg (7-12D preg)
TDLo: skn-rat 1200 mg/kg (10-11D preg)
TDLo: orl-rbt 910 mg/kg (6-18D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89)
Final Limit: PEL-TWA 20 ppm, STEL 30 ppm [015,545,610]
ACGIH: TLV-TWA 10 ppm (skin) [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 1
Reactivity (R): None
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 23 mg
Status: EPA Genetox Program 1988, Negative: Cell transform.-RLV F344
rat embryo
EPA TSCA Chemical Inventory, 1986
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Test Submission (TSCATS) Data Base, June 1989
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This compound is used in the manufacture of formates and hydrocyanic acid.
It is also used as a softener for paper, gums and animal glues, as an ionizing
and pharmaceutical solvent and as a versatile synthetic reagent.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS: Not available
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PE/EVAL/PE Safety 4 4H 0.07 mm 240 min
Butyl rubber North B-161 0.41 mm 240 min
Butyl rubber/Neoprene Comasec DipioButyl 0.60 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture. If possible, it would be prudent to
store this compound under inert atmosphere.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the skin
and eyes [043,051]. Other symptoms may include irritation of the respiratory
tract, headache, dizziness, nausea, vomiting, abdominal pain, unconsciousness,
central nervous system effects, liver damage and kidney damage. Redness and
pain may occur on contact with the eyes and skin. Corneal damage may occur
[058]. Corrosion may also occur [043]. This compound may also cause con-
genital malformation in the fetus [269]. Alcohol consumption enhances the
toxic effects of this chemical [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. LQ0525000.
October 13, 1989.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-278, #7058.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 3, p. 2676, #F00658.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 605, #4121.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. p. 345.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 518.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. III, p. 1766, #FMY000.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 642, #F00222.
[051] Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials
Report. Bi-monthly Updates. Van Nostrand Reinhold Company, Inc.
New York. September/October 1980; Vol. 1, No. 1, p. 44.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
p. 683.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. October/November
1989. #1451-006, A-07; #5846-078, G-01.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 537.
[066] Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd Ed.
Butterworths. London. 1985. pp. 158-159.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. p. 1036.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[186] Sittig, Marshall, Ed. Pesticide Manufacturing and Toxic Materials
Control Encyclopedia. Noyes Data Corporation. Park Ridge, NJ.
1980. p. 452.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-418, #f102.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 979.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 763, #29,587-6.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. p. 1454.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 155.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. p. 465.
[415] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 22.
[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 278.
[451] National Fire Protection Association. Fire Protection Guide on
Hazardous Materials. 9th Ed. National Fire Protection
Association. Quincy, MA. 1986. p. 325M-54.
[545] Office of the Federal Register National Archives and Records
Administration. Federal Register, Dept. of Labor, Part III.
U.S. Government Printing Office. Washington. January 19, 1989.
p. 2938.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 16.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
[650] 3M Company. 1989 Respirator Selection Guide. 3M Occupational Health
and Environmental Safety Division. St. Paul, MN. 1989. p. 20.
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