NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
DIMETHYL METHYLPHOSPHONATE
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IDENTIFIERS
CATALOG ID NUMBER: 000578
CAS NUMBER: 756-79-6
BASE CHEMICAL NAME: DIMETHYLMETHYLPHOSPHONATE
PRIMARY NAME: DIMETHYL METHYLPHOSPHONATE
CHEMICAL FORMULA: C3H9O3P
STRUCTURAL FORMULA: CH3PO(OCH3)2
WLN: 1OPO&1&O1
SYNONYMS:
METHYLPHOSPHONIC ACID DIMETHYL ESTER
METHANEPHOSPHONIC ACID DIMETHYL ESTER
DMMP
NCI-C54762
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 124.08
SPECIFIC GRAVITY: 1.1596 @ 25/22 C [052]
DENSITY: 1.145 g/mL [205,269,275]
MP (DEG C): Not available
BP (DEG C): 181 C [205,269,275]
SOLUBILITIES:
WATER : >=100 mg/mL @ 21 C (RAD)
DMSO : >=100 mg/mL @ 21 C (RAD)
95% ETHANOL : >=100 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
VOLATILITY:
Vapor pressure: 1.2 mm Hg @ 25 C [058]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 43 C (110 F) [205,269,275]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [058,269].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizing agents and strong
bases [269]. It reacts with organic halides at 150-200 C. When heated to
temperatures greater than 150 C, it will act as an alkylating agent with basic
nitrogen compounds and phenols [058]. It reacts with enol lactones [275].
This compound has plasticizing properties and may soften or deteriorate some
plastics and elastomers (particularly vinyl-based resins, neoprene and natural
rubbers) upon contact [058].
STABILITY:
This chemical will hydrolyze slowly upon contact with water [058]. NMR
stability screening indicates that solutions of this chemical in DMSO are
stable for at least 24 hours (RAD).
OTHER PHYSICAL DATA:
Specific gravity: 1.17 @ 25/25 C [058]
Boiling point: 92-97 C @ 50 mm Hg [025]; 79.5 C @ 20 mm Hg [016,047]
Boiling point: 66-68 C @ 10 mm Hg [027]
Refractive index: 1.4130 @ 20 C [205,269,275]
Pour point: <-50 C [058]
Viscosity: 4 centipoise @ 25 C [058]
Pleasant odor [027]
TOXICITY
NIOSH REGISTRY NUMBER: SZ9120000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat >5000 mg/kg [058]
LD50 skn rbt >2000 mg/kg [058]
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Experimental reproductive effects. Mutagenic data. A suspected
carcinogen.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies (Gavage); Some Evidence: Male Rat [620]
NTP Carcinogenesis Studies (Gavage); No Evidence: Female Rat and
Male Mouse [620]
NTP Carcinogenesis Studies (Gavage); Inadequate Study: Male Mouse
[620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
cyt-ham:ovr 250 mg/L | dlt-mus-orl 65 gm/kg/13W-C
sce-ham:ovr 11 gm/L |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-mus 10 gm/kg (20D male)
TDLo: orl-mus 33 gm/kg (7-14D preg)
TDLo: orl-rat 63 gm/kg (63D male)
TDLo: orl-rat 126 gm/kg (63D male)
TDLo: orl-rat 15750 mg/kg (63D male)
TDLo: orl-mus 33400 mg/kg (6-13D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Flammable liquids, n.o.s.
(Dimethyl methylphosphonate)
UN/ID NUMBER: UN1993
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
This chemical is used as a gasoline additive, hydraulic fluid additive,
heavy metal extractor, solvent, stimulant for nerve gas agents, additive flame
retardent in plastics, extractant for rare earths and synthetic intermediate.
It forms an anion which may be alkylated or acylated. It is also used to
methylate nucleotide bases and to convert carboxylic acids into methyl esters.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical may be harmful by inhalation, ingestion or skin absorption.
It is an irritant of the skin, eyes, mucous membranes and upper respiratory
tract [269]. When heated to decomposition it emits toxic fumes of carbon
monoxide, carbon dioxide, phosphorus oxides and phosphine [043,058,269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Neoprene Edmont 29-865 0.51 mm 360 min
Nitrile Edmont 37-165 0.60 mm 360 min
PE/EVAL/PE Safety 4 4H 0.07 mm 240 min
PVC Edmont Snorkel 0.19 mm 360 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical under ambient temperatures,
and protect it from moisture. If possible, it would be prudent to
store this compound under inert atmosphere.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the
skin, eyes, mucous membranes and upper respiratory tract [269]. Combustion
products may cause breathing difficulty and pulmonary edema [058]. It has
weak cholinesterase inhibiting properties [052].
Symptoms of exposure in animals via ingestion include a decrease in
physical activity, ataxia, chromodacryorrhea and ruffled fur [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. SZ9120000.
August 1, 1989.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-351, #9111.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 4, p. 871, #M-03326.
[027] Edmundson, R.S. Ed. Dictionary of Organophosphorus Compounds.
Chapman and Hall. New York. 1988. p. 312, #D-00762.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, p. 1408, #DSR400.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 843, #M00442.
[052] Midwest Research Institute. MRI Report for Dimethyl methylphosphonate.
Kansas City, MO. May 29, 1978; June 7, 1982.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. August/September 1989.
#1060-028, A-04.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-348, #d1074.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 782, #B.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 611, #D16,910-2.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. p. 367.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 80.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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