NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002261
CAS NUMBER: 9004-67-5
BASE CHEMICAL NAME: METHYLCELLULOSE
PRIMARY NAME: METHYL CELLULOSE
CHEMICAL FORMULA: (C7H14O5)x
STRUCTURAL FORMULA: Not printable
WLN: Not available
SYNONYMS:
METHYL ETHER CELLULOSE (1/2%)
ADULSIN
BAGOLAX
BUFAPTO METHALOSE
BULKALOID
CELACOL M
CELACOL M20
CELACOL M450
CELACOL MM
CELACOL MM 10P
CELACOL M 20P
CELLAPRET
CELLOGRAN
CELLOTHYL
CELLULOSE METHYL
CELLULOSE METHYLATE
CELLUMETH
CETHYLOSE
CETHYTIN
CULMINAL K 42
EDISOL M
HYDROLOSE
MAPOLOSE M25
MAPOLOSE 60SH50
MCO 8000
MC 4000 CP
MC 20000S
MELLOSE
METHOCEL 10
METHOCEL 15
METHOCEL 181
METHOCEL 400
METHOCEL 4000
METHOCEL A
METHOCEL CHG
METHOCEL 400CPS
METHOCEL 4000CPS
METHOCEL MC
METHOCEL MC 25
METHOCEL MC4000
METHOCEL MC 8000
METHOCEL SM 100
METHULOSE
METHYLCELLULOSE (1/2%)
METHYL CELLULOSE-A
METHYL CELLLULOSE ETHER
METOLOSE MC 8000
METOLOSE 60SH
METOLOSE 60SH400
METOLOSE SM 15
METOLOSE SM 100
METOLOSE SM 4000
MMTS-BTR
MTS
NAPOLONE
NICEL
RHOMELLOSE
SYNCELOSE
TYLOSE 444
TYLOSE A4S
TYLOSE MF
TYLOSE MH
TYLOSE MH20
TYLOSE MH50
TYLOSE MH300
TYLOSE MH1000
TYLOSE MH2000
TYLOSE MH4000
TYLOSE MH300P
TYLOSE SAP
TYLOSE SL
TYLOSE SL 100
TYLOSE SL 400
TYLOSE SL 600
TYLOSE TWA
USP METHYLCELLULOSE
VISCOL
VISCONTRAN L52
VISCOSOL
WALSRODER MC 20000S
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White or creamy white, fibrous powder
REPOSITORY: White powder
MOLECULAR WEIGHT: 40,000 to 180,000
SPECIFIC GRAVITY: Not available
DENSITY: Not available
MP (DEG C): Decomposes upon heating from 250 C to 300 C [052]
BP (DEG C): Not available
SOLUBILITIES:
WATER : 5-10 mg/mL @ 17 C (RAD)
DMSO : 1-10 mg/mL @ 17 C (RAD)
95% ETHANOL : <1 mg/mL @ 17 C (RAD)
METHANOL : Not available
ACETONE : <1 mg/mL @ 17 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Insoluble [062,295]
Glacial acetic acid: Soluble [062,900]
Alcohol and chloroform (50:50): Soluble [295]
Chloroform: Insoluble [062,295]
Ether: Insoluble [062,295]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with a
dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [058].
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with strong oxidizing agents [269]. It is
also incompatible with aminacrine HCl, chlorocresol, mercuric chloride, phenol,
resorcinol, tannic acid and silver nitrate [058,295].
STABILITY:
This compound is hygroscopic [295,455].
OTHER PHYSICAL DATA:
Odorless [031,900]
Swells in water to a viscous, colloidal solid [062]
Tasteless [062]
Minimum explosive dust concentration: 0.03 oz./ft3 [900]
Dust exlosion hazard: a class St-1 [058]
TOXICITY
NIOSH REGISTRY NUMBER: FJ5959000
TOXICITY:
typ. dose mode specie amount units other
LD50 ipr mus 275 gm/kg
LDLo ivn mus 1 gm/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Not available
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
Not available |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA TSCA Chemical Inventory, 1986
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used in Citrucel a dietary fiber laxative, as a
protective colloid in water-based paints to prevent flocculaton of pigment,
in film and sheeting, binder in ceramic glazes, leather tanning, dispersing and
sizing agent, binding and disintegrating agents in tablets, substitute for
water soluble gums, to render paper grease proof, as thickening agent in
cosmetics, as protective colloid in emulsions and as binder and stabilizer in
foods. A 1 or 2% solution has been used clinically as a lubricant aid to the
insertion of intraocular lenses, adhesive in plaster of Paris, a demulcent
widely used in contact lens solution, artificial tears, other ophthalmic
preparations for nose drops and other drugs that act locally.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is harmful if inhaled, ingested or absorbed through the skin
[269]. It may cause irritation to the eyes. When heated to decomposition it
emits toxic fumes of carbon monoxide and carbon dioxide [900].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl North B-161 0.58 mm 240 min
PVA Edmont 25-950 0.33 mm 240 min
Neoprene Edmont 29-870 0.41 mm 240 min
PE/EVOH/PE Safety 4 4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
This compound should be protected from moisture and stored at ambient
temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water, then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include cause intestinal
obstruction, skin sensitization and chemical pneumonitis [301]. It may cause
irritation to the eyes [900].
SOURCES
SOURCES:
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of Chemical Substances. On-line Ed. National Institute for
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June 6, 1989.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 866, #5917.
[052] Midwest Research Institute. MRI Report for Methyl cellulose.
Kansas City, MO. Sept. 14, 1988.
[058] Information Handling Services. Material Safety Data Sheets
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1989. #5950-002, C-01.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
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p. 763.
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[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. p. 611.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
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Laboratory. Oak Ridge, TN. Not listed.
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Laboratory. Oak Ridge, TN. Listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
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[164] Huff, B.B., Ed. Physicians' Desk Reference for Nonprescription Drugs.
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[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
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[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
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p. 1266, #A.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
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1988. p. 998.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. pp. 947-948.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. pp. 308, 477.
[327] Office of the Federal Register National Archives and Records
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[406] Goodman, L.S., A. Gilman, F. Murad and T.W. Rall, Eds. The
Pharmacological Basis of Therapeutics. 7th Ed. Macmillan
Publishing Co. New York. 1985. pp. 946, 997.
[415] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 29.
(Nuisance Particulates)
[421] American Conference of Governmental Industrial Hygienists.
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American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 445 (Nuisance Particulates).
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and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIA, pp. 2552-2553.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
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[545] Office of the Federal Register National Archives and Records
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U.S. Government Printing Office. Washington. January 19, 1989.
p. 2947 (Particulates not Otherwise Regulated).
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Not listed.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
[900] Midwest Research Institute. Material Safety Data Sheet for Mehtyl
cellulose. #414N.
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