NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000423
CAS NUMBER: 91-59-8
BASE CHEMICAL NAME: NAPHTHYLAMINE,2-
PRIMARY NAME: 2-NAPHTHYLAMINE
CHEMICAL FORMULA: C10H9N
STRUCTURAL FORMULA: C10H7NH2
WLN: L66J CZ
SYNONYMS:
2-AMINONAPHTHALENE
2-NAPHTHALAMINE
2-NAPHTHALENAMINE
BETA-NAPHTHYLAMINE
6-NAPHTHYLAMINE
2-NAPHTHYLAMINE MUSTARD
FAST SCARLET BASE B
C.I. 37270
RCRA WASTE NUMBER U168
UN 1650
USAF CB-22
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White to reddish crystals
REPOSITORY: Off-white powder
MOLECULAR WEIGHT: 143.18
SPECIFIC GRAVITY: 1.061 @ 98/4 C [033,043,055,421]
DENSITY: 1.061 g/mL [269,275]
MP (DEG C): 111-113 C [033,205,275,395]
BP (DEG C): 306 C [033,043,275,395]
SOLUBILITIES:
WATER : <1 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 20.5 C (RAD)
95% ETHANOL : 5-10 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [016,033,043,205]
Ether: Soluble [016,033,043,205]
Many other organic solvents: Soluble [395]
VOLATILITY:
Vapor pressure: 1 mm Hg @ 108.0 C [038,043,051]; 5 mm Hg @ 141.6 C [038]
Vapor density : 4.95 [055]
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. At elevated temperatures, this chemical evolves a vapor
which is flammable and explosive [043]. Fires involving this material can be
controlled with a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is a weak base [395]. It is incompatible with strong
oxidizing agents and strong acids [269]. It is also incompatible with nitrous
acid [043,066]. It reduces warm ammoniacal silver nitrate [033,051].
STABILITY:
This chemical darkens in air to a reddish-purple color (oxidizes) [395].
UV spectrophotometric stability screening indicates that solutions of this
chemical in 95% ethanol are stable for at least 24 hours (RAD).
OTHER PHYSICAL DATA:
Refractive index: 1.6493 @ 98 C [016,047]
Melting point (commercial grade): 109.5 C [062]
Boiling point also reported as 294 C [029,033,043]
Boiling point: 158 C @ 10 mm Hg [395]
pKa 9.69 [029]
Volatile with steam [029,033,051,395]
log P octanol: 2.25 (calculated) [055]
Faint aromatic odor [043,051]
Odor threshold concentration (recognition): 1.4-1.9 mg/m3 [055]
Vapor pressure: 10 mm Hg @ 157.6 C; 20 mm Hg @ 175.8 C [038]
Vapor pressure: 40 mm Hg @ 195.7 C; 60 mm Hg @ 208.1 C [038]
Vapor pressure: 100 mm Hg @ 224.3 C; 200 mm Hg @ 249.7 C [038]
Vapor pressure: 400 mm Hg @ 277.4 C; 760 mm Hg @ 306.1 C [038]
TOXICITY
NIOSH REGISTRY NUMBER: QM2100000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 727 mg/kg
LD50 ipr mus 200 mg/kg
LDLo unr dog 500 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intraperitoneal route. Moderately toxic by ingestion and
possibly other routes. A human and experimental carcinogen. An
experimental neoplastigen, tumorigen and teratogen. Human mutagenic
data. A very toxic chemical in any of its physical forms, such as flake,
lump, dust, liquid or vapor. It can be absorbed into the body through
the lungs, the gastrointestinal tract or the skin. Long and continued
exposure to even small amounts may produce tumors and cancers of the
bladder.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 17100 mg/kg/57W-I
TDLo: ipr-rat 1300 mg/kg/13W-I
TDLo: scu-rat 6 gm/kg/60W-I
TDLo: orl-mus 600 mg/kg/8W-I
TDLo: ipr-mus 1500 mg/kg/8W-I
TDLo: scu-mus 1600 mg/kg/40W-I
TDLo: par-mus 18 mg/kg
TDLo: imp-mus 100 mg/kg
TDLo: orl-dog 18 gm/kg/2Y-I
TDLo: unr-dog 40 gm/kg/81W
TDLo: mul-dog 3077 mg/kg/78W-C
TDLo: orl-mky 17 gm/kg/5Y-I
TDLo: orl-rbt 40 gm/kg/5Y
TDLo: orl-ham 217 mg/kg/45W-C
TD : orl-ham 365 gm/kg/43W-C
TD : orl-dog 108 mg/kg/4Y
TD : orl-mus 31 gm/kg/2Y
TD : orl-rbt 30 gm/kg/5Y
TD : mul-dog 4379 mg/kg/80W-C
TD : scu-mus 80 mg/kg
TD : orl-rat 13 gm/kg/1Y-I
TD : mul-dog 5169 mg/kg/91W-C
TD : orl-rat 16 gm/kg/52W-I
TD : orl-dog 94500 mg/kg/9Y-I
Review: IARC Cancer Review; Human Sufficient Evidence
IARC Cancer Review; Animal Sufficient Evidence
IARC human carcinogen (Group 1) [015,395,610]
ACGIH confirmed human carcinogen [015,415,421,610]
Status: OSHA cancer suspect agent [015,327,610]
NTP Fifth Annual Report on Carcinogens, 1989: Known to be carcinogenic
[015,610]
EPA Carcinogen Assessment Group [610]
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: See Carcinogenicity
ACGIH: See Carcinogenicity
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review-3
Standards and Regulations: DOT-IMO: Poison B; Label: Poison
Status: EPA Genetox Program 1988, Positive: Carcinogenicity-mouse/rat; SHE-
clonal assay
EPA Genetox Program 1988, Positive: Cell transform.-mouse embryo
EPA Genetox Program 1988, Positive: Cell transform.-RLV F344 rat
embryo
EPA Genetox Program 1988, Positive: Cell transform.-SA7/SHE; Host-
mediated assay
EPA Genetox Program 1988, Positive: Mammalian micronucleus; N crassa-
forward mutation
EPA Genetox Program 1988, Positive: E coli polA with S9; Histidine
reversion-Ames test
EPA Genetox Program 1988, Positive: S cerevisiae gene conversion
EPA Genetox Program 1988, Negative: Cell transform.-BALB/c-3T3; E coli
polA without S9
EPA Genetox Program 1988, Negative: Sperm morphology-mouse; S
cerevisiae-homozygosis
EPA Genetox Program 1988, Inconclusive: D melanogaster Sex-linked
lethal
EPA Genetox Program 1988, Positive: CHO gene mutation
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
NIOSH Analytical Methods: see Naphthylamines, 5518
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): beta-Naphthylamine
UN/ID NUMBER: UN1650
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 613, Y613 MAXIMUM QUANTITY: 25 kg, 1 kg
CARGO : PKG. INSTR.: 615 MAXIMUM QUANTITY: 100 kg
SPECIAL PROVISIONS: None
USES:
This compound is presently used only for research purposes. It was
widely used in the manufacture of dyes, as an antioxidant for rubber and in
rubber-coated cables.
COMMENTS:
The manufacture and use of this compound is now banned due to its
carcinogenic properties [029]. The use of this compound in the United
Kingdom is now prohibited under The Carcinogenic Substances Regulations
1967 [029,043].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion and inhalation [062,269]. It can
be absorbed through the lungs and gastrointestinal tract [051]. It is an
irritant of the eyes [301]. It is also a mild irritant of the skin [346].
When heated to decomposition it emits toxic fumes of carbon monoxide, carbon
dioxide and nitrogen oxides [043,269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-161 0.40 mm 480 min
Natural rubber Pioneer L-118 0.46 mm 480 min
PVC Edmont PVC Unknown 180 min
Unknown North Silvershield 0.10 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
SPILLS AND LEAKAGE:
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION,
then you should dampen the solid spill material with acetone and transfer the
dampened material to a suitable container. Use absorbent paper dampened with
acetone to pick up any remaining material. Seal your contaminated clothing
and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with acetone followed by washing with
a soap and water solution. Do not reenter the contaminated area until the
Safety Officer (or other responsible person) has verified that the area has
been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include mild irritation of the
skin, contact dermatitis, frequent urination, dysuria, methemoglobinemia,
hematuria and acute hemorrhagic cystitis [346]. Other symptoms include eye
irritation, corneal damage, bladder irritation, kidney damage and liver damage
[301].
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