NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001467
CAS NUMBER: 96-23-1
BASE CHEMICAL NAME: DICHLOROPROPANOL,1,3-,2-
PRIMARY NAME: 1,3-DICHLORO-2-PROPANOL
CHEMICAL FORMULA: C3H6Cl2O
STRUCTURAL FORMULA: ClCH2CH(OH)CH2Cl
WLN: G1YQ1G
SYNONYMS:
GLYCEROL 1,3-DICHLOROHYDRIN
ALPHA-DICHLOROHYDRIN
SYM-GLYCEROL DICHLOROHYDRIN
GLYCEROL ALPHA,GAMMA-DICHLOROHYDRIN
SYM-DICHLOROISOPROPYL ALCOHOL
DICHLOROHYDRIN
1,3-DICHLOROPROPANOL-2
2-PROPANOL, 1,3-DICHLORO-
ENODRIN
UN 2750
U 25,354
ALPHA,GAMMA-DICHLOROHYDRIN
1,3-DICHLORO-2-HYDROXYPROPANE
1,3-DICHLOROISOPROPANOL
PROPYLENE DICHLOROHYDRIN
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless, slightly viscous liquid
REPOSITORY: Yellow viscous liquid
MOLECULAR WEIGHT: 128.99
SPECIFIC GRAVITY: 1.3506 @ 17/4 C [016,031,047,205]
DENSITY: 1.36-1.39 g/mL [062]
MP (DEG C): -4 C [031,043,062,275]
BP (DEG C): 174 C [036,043,062,451]
SOLUBILITIES:
WATER : >=100 mg/mL @ 23 C (RAD)
DMSO : >=100 mg/mL @ 23 C (RAD)
95% ETHANOL : >=100 mg/mL @ 23 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 23 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: Miscible [031,205]
Vegetable oils: Miscible [062]
Most organic solvents: Miscible [062]
Alcohol: Miscible [031,205]
VOLATILITY:
Vapor pressure: 1 mm Hg @ 28.0 C [038,043]; 5 mm Hg @ 52.2 C [038]
Vapor density : 4.45 [043]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 74 C (165 F) [043,062,451]. It
is combustible. Fires involving this material can be controlled with a
dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with oxidizers [043,269]. It is also
incompatible with strong acids, strong reducing agents, acid chlorides and
acid anhydrides [269].
STABILITY:
This chemical is sensitive to heat [043].
OTHER PHYSICAL DATA:
Specific gravity: 1.367 @ 20/4 C [043]
Boiling point: 69 C @ 12 mm Hg [016,047]; 114.8 C @ 100 mm Hg [031]
Boiling point: 93 C @ 40 mm Hg; 78 C @ 20 mm Hg; 52 C @ 5 mm Hg [031]
Boiling point: 28 C @ 1 mm Hg [031]
Refractive index: 1.480245 @ 17 C [031]; 1.4835 @ 20 C [205,269,275]
Flash point also reported as 85 C (186 F) [269,275]
Vapor pressure: 10 mm Hg @ 64.7 C, 20 mm Hg @ 78.0 C, 40 mm Hg @ 93.0 C [038]
Vapor pressure: 60 mm Hg @ 102.0 C, 100 mm Hg @ 114.8 C [038]
Vapor pressure: 200 mm Hg @ 133.3 C, 400 mm Hg @ 153.5 C [038]
Ethereal odor [036,043]
TOXICITY
NIOSH REGISTRY NUMBER: UB1400000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 110 mg/kg
LCLo ihl rat 125 ppm/4H
LD50 skn rbt 800 mg/kg
LD50 orl mus 100 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion and inhalation. Moderately toxic by skin contact.
Human mutagenic data. A skin irritant. Action may be similar to carbon
tetrachloride, but more irritating to mucous membranes.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-sat 1 umol/plate | mma-sat 100 ug/plate
dni-hmn:hla 2500 umol/L | sce-ham:lng 250 umol/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 2
Reactivity (R): 0
and which are not reactive with water (see NFPA for details).
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 mg/24H open MLD
Standards and Regulations: DOT-IMO: Poison B; Label: Poison
Status: EPA Genetox Program 1988, Positive: Histidine reversion-Ames test
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, June 1989
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): 1,3-Dichloropropanol-2
UN/ID NUMBER: UN2750
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 609, Y609 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 611 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used as a general solvent, as an intermediate in
organic synthesis and in paints, varnishes, lacquers, water colors, binders
and photographic lacquers. It is also used as a solvent for hard resins
and nitrocellulose, in the manufacture of zapon lacquer and as a cement from
celluloid.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by inhalation and ingestion [025]. It is
also harmful if absorbed through the skin [269]. It is an irritant of
the skin, eyes, mucous membranes and upper respiratory tract [036,269].
When heated to decomposition it emits highly toxic fumes of carbon monoxide,
carbon dioxide, hydrogen chloride gas and phosgene gas [043,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-174 0.63 mm 240 min
Viton North F-091 0.25 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and keep it away from oxidizing materials.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include hemorrhagic gastritis
and pharyngitis [151]. Other symptoms include headache, vertigo, nausea,
vomiting, pulmonary edema and liver damage [036].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. UB1400000.
December 4, 1989.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-447, #11988.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 2, p. 1776, #D-03131.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 446, #3058.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. p. 285.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 520.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, p. 1173, #DGG400.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
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[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
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p. 379.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
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[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. p. 1030.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-177, #433.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-294, #d421.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 636, #B.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 507, #18,448-9.
[451] National Fire Protection Association. Fire Protection Guide on
Hazardous Materials. 9th Ed. National Fire Protection
Association. Quincy, MA. 1986. p. 325M-35.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
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[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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